2026, Number S1
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Rev Mex Anest 2026; 49 (S1)
New paradigms in pain control: Nav 1.8 inhibitors
Roldán-Rodríguez E
Language: Spanish
References: 10
Page: 79-81
PDF size: 740.13 Kb.
Text Extraction
No abstract.
REFERENCES
Osteen JD, Immani S, Tapley TL, Indersmitten T, Hurst NW, HealeyT, et al. Pharmacology and mechanism of action of suzetrigine, apotent and selective NaV1.8 pain signal inhibitor for the treatment ofmoderate to severe pain. Pain Ther. 2025;14:655-674. doi: 10.1007/s40122-024-00697-0.
Medhat RM, Kotb OA, Baecker D. Suzetrigine, a NaV1.8 inhibitor as anovel approach for pain therapy-a medicinal and chemical drug profile.Molecules. 2026;31:358. doi: 10.3390/molecules31020358.
Rajasingham R, Qi Y. Suzetrigine, a non-opioid small-moleculeanalgesic: mechanism of action, clinical, and translational science. ClinTransl Sci. 2025;18:e70414. doi: 10.1111/cts.70414.
Pham A, Yep H, Wozniak S, Javvaji A, Nada E, Bergese S. Beyondopioids: a review of suzetrigine for acute pain management. Int J MolSci. 2025;26:9865. doi: 10.3390/ijms26209865.
Rejeev MM, Pavithran K, Palatty P. Clinical efficacy and safety profileof suzetrigine: a novel non-opioid analgesic targeting NaV1.8 sodiumchannel. Cureus. 2025;17:e96054. doi: 10.7759/cureus.96054.
Alvarez-Aguilar P, Picado-Loaiza S. Suzetrigine (a NaV1.8 inhibitor)versus placebo for acute postoperative pain: A systematic review andmeta-analysis of randomized controlled trials. Medicine (Baltimore).2026;105:e47877. doi: 10.1097/MD.0000000000047877.
AlDoughaim M, AlSuhebany N, AlZahrani M, AlDairem A, AlghamdiSS. Transforming pain management: suzetrigine, a novel non-opioidanalgesic. Biomol Ther (Seoul). 2025;33:934-939. doi: 10.4062/biomolther.2025.046.
Hang Kong AY, Tan HS, Habib AS. VX-548 in the treatment of acute pain.Pain Manag. 2024;14:477-486. doi: 10.1080/17581869.2024.2421749.
Keam SJ. Suzetrigine: First Approval. Drugs. 2025;85(6): 845-851. doi: 10.1007/s40265-025-02178-w.
Wu Z, Lu D. Advances in the discovery of selective NaV1.8 inhibitors forpain management. Eur J Med Chem. 2026;302:118326. doi: 10.1016/j.ejmech.2025.118326.
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