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2026, Number S1

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Rev Mex Anest 2026; 49 (S1)

Propofol: from classical pharmacology to a precision tool

Calixto-Flores A
Full text How to cite this article

Language: Spanish
References: 14
Page: 457-460
PDF size: 751.01 Kb.


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REFERENCES

  1. Su H, Eleveld DJ, Colin P, Vereecke HEM, Heylen RJ, Soltész K,et al. Mechanism-based pharmacodynamic model for propofolinducedhaemodynamic effects in healthy volunteers. Br J Anaesth. 2022;128:806-816.

  2. Glen JB. The discovery and development of propofol anesthesia: the2018 Lasker-DeBakey Clinical Medical Research Award. JAMA.2018;320:1235-1236.

  3. Cao SJ, Zhang Y, Zhang YX, Song QJ, Shan GJ, Xu XJ, et al. Delirium inolder patients given propofol or sevoflurane anaesthesia for major cancersurgery: a multicentre randomised trial. Br J Anaesth. 2023;131:253-265.

  4. Su H, Eleveld DJ, Colin P, Vereecke HEM, Heylen RJ, van GervenJMA, et al. Pharmacodynamic mechanism-based interaction modelfor the haemodynamic effects of remifentanil and propofol in healthyvolunteers. Br J Anaesth. 2023;131:264-273.

  5. Eleveld DJ, Colin P, Absalom AR, Struys MMRF. Pharmacokineticpharmacodynamicmodel for propofol for broad application inanaesthesia and sedation. Br J Anaesth. 2018;120:942-959.

  6. Vellinga R, Hannivoort LN, Introna M, Touw DJ, Eleveld DJ, VereeckeH, et al. Prospective clinical validation of the Eleveld propofolpharmacokinetic-pharmacodynamic model in general anaesthesia. BrJ Anaesth. 2021;126:386-394.

  7. Coetzee E, Coetzee JF, Haasbroek M. Predictive pharmacodynamicperformance of the Eleveld pharmacokinetic-pharmacodynamic modelfor propofol: comparison of predicted and measured bispectral index.Br J Anaesth. 2024;133:780-788.

  8. Driesens MK, Barends CRM, Eleveld DJ, Struys MMRF. Prospectiveclinical evaluation of the Eleveld pharmacokinetic and pharmacodynamicmodel of propofol for moderate-to-deep sedation in adults. Eur JAnaesthesiol. 2026;43:e1-e9.

  9. Shao YR, Kahali P, Houle TT, Deng H, Colvin C, Dickerson BC, etal. Low frontal alpha power is associated with the propensity for burstsuppression: an electroencephalogram phenotype for a vulnerable brain.Anesth Analg. 2020;131:1529-1539.

  10. Zhang Y, Shan GJ, Zhang YX, Cao SJ, Zhu SN, Li HJ, et al. Propofolcompared with sevoflurane general anaesthesia is associated withdecreased delayed neurocognitive recovery in older adults. Br J Anaesth.2018;121:595-604.

  11. Fang P, Gao J, Wang X, Shan W, Liu Y, Fang Z, et al. Contribution ofintraoperative electroencephalogram suppression to frailty-associatedpostoperative delirium: mediation analysis of a prospective surgicalcohort. Br J Anaesth. 2023;130:e263-e271.

  12. Hüppe T, Maurer F, Sessler DI, Volk T, Kreuer S. Retrospectivecomparison of Eleveld, Marsh, and Schnider propofol pharmacokineticmodels in 50 patients. Br J Anaesth. 2020;124:e22-e24.

  13. Short TG. Increasing the utility of target-controlled infusions: one modelto rule them all. Br J Anaesth. 2018;120:887-890.

  14. Hemphill S, McMenamin L, Bellamy MC, Hopkins PM. Propofolinfusion syndrome: a structured literature review and analysis ofpublished case reports. Br J Anaesth. 2019;122:448-459.




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Rev Mex Anest. 2026;49