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Organo Oficial de la Sociedad Mexicana de Urología

2026, Number 2

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Rev Mex Urol 2026; 86 (2)

Renal primitive neuroectodermal tumor-Ewing’s sarcoma. Literature review and case report

García-Castillo EC, Contreras-Solís MF, Uribe-Uribe NO, Rodríguez-Covarrubias F

Language: Spanish
References: 18
Page: 1-9
PDF size: 356.55 Kb.


ABSTRACT

Case description: a 26-year-old woman with a history of HIV and triple-negative breast cancer in remission presented with low back pain, fever, and weight loss. Contrast-enhanced computed tomography revealed a right renal mass. An open radical nephrectomy was performed, and histopathological analysis confirmed a primitive neuroectodermal tumor (PNET), with immunohistochemistry positive for CD99 and FLI-1. Despite receiving one cycle of adjuvant chemotherapy, the patient experienced rapid disease progression and opted for palliative care, dying seven months after surgery.
Relevance: renal primitive neuroectodermal tumors are rare and aggressive neoplasms often misdiagnosed as other renal tumors. They are characterized by high recurrence rates and rapid metastatic dissemination.
Clinical implications: the management of these rare and aggressive tumors requires a multimodal therapeutic approach, including surgery, chemotherapy, and, in selected cases, radiotherapy.
Conclusions: the detection of renal tumors has increased due to the widespread use of imaging studies. However, early identification of rare and aggressive tumors remains a challenge, hindering timely and appropriate management.


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