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2026, Number 3

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Rev Mex Pediatr 2026; 93 (3)

Coverage of the immunization schedule among patients with inborn errors of metabolism

Rivera-Comparan EA, Cañavera-García V, Peregrino-Bejarano L, Alegría-Torres GA, Villasís-Keever MÁ, Zurita-Cruz J

Language: Spanish
References: 20
Page: 109-115
PDF size: 825.84 Kb.


ABSTRACT

Introduction: vaccination is one of the most effective interventions for preventing infectious diseases. Among patients with inborn errors of metabolism (IEM), a perception persists that immunization may trigger metabolic decompensation, even though guidelines do not establish specific contraindications. Objective: to describe the frequency of complete vaccination schedules in pediatric patients diagnosed with IEM treated at a tertiary-care hospital. Material and methods: an observational, cross-sectional, descriptive study was conducted on patients younger than 18 years of both sexes with a confirmed diagnosis of IEM, receiving outpatient care at Hospital de Pediatría, Centro Médico Nacional Siglo XXI during 2024. Results: fifty-five patients were evaluated; 61.8% were male. Forty percent had a complete vaccination schedule for their age, a figure that reached 66% among those under two years old. Regarding specific vaccines, the highest coverage rates were observed for BCG (100%), pentavalent/hexavalent (100%), and pneumococcal conjugate (100%) for the first two doses and 90.9% for the third. Influenza and MMR (measles, mumps, and rubella) vaccines showed the lowest compliance. The main reasons for incomplete vaccination were a lack of parental motivation, incorrect contraindications, and vaccine shortages. The frequency of adverse events supposedly attributable to vaccination was 18.1%. Conclusions: among the pediatric population with IEM, less than half have a complete vaccination schedule, with influenza and MMR vaccines showing the lowest compliance.


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