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2026, Number 4

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Rev ADM 2026; 83 (4)

Dental regeneration: from myths to milestones in biological restoration to the regenerative dentistry of the future.

Zerón A

Language: Spanish
References: 20
Page: 195-201
PDF size: 4109.39 Kb.


ABSTRACT

     


REFERENCES

  1. Regeneración dental mediante inhibición de USAG-1
    El artículo fundacional que impulsó el desarrollo de la terapia de regeneración dental basada en USAG-1 es:
    1. Murashima-Suginami A, Kiso H, Tokita Y, Mihara E, Nambu Y, Uozumi R et al. Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling. Sci Adv. 2021; 7 (7): eabf1798.

  2. Ravi V, Murashima-Suginami A, Kiso H, Tokita Y, Huang CL, Bessho K et al. Advances in tooth agenesis and tooth regeneration. Regen Ther. 2023; 22: 160-168.

  3. Takahashi K, Kiso H, Mihara E, Takagi J, Tokita Y, Murashima-Suginami A. Development of a new antibody drug to treat congenital tooth agenesis. J Oral Biosci. 2024; 66 (4): 1-9.

  4. Moradi Z, Karimi M, Kolahdouz S, Arya N, Akheshteh V, Ayanzadeh F et al. USAG-1 and Regenerative Dentistry, Therapeutic Implications and Future Directions: Review of the Literature. Clin Exp Dent Res. 2026; 12 (1): e70301.

  5. Regeneración de dentina y Tideglusib
    Tideglusib actúa inhibiendo GSK-3 y activando la vía Wnt/β-catenina, promoviendo la movilización de células madre pulpares y la formación de dentina reparativa (PMC). La evidencia más sólida proviene del grupo de investigación del King's College London.
    5. Neves VC, Babb R, Chandrasekaran D, Sharpe PT. Promotion of natural tooth repair by small molecule GSK3 antagonists. Sci Rep. 2017; 7: 39654.

  6. Neves VCM, Sharpe PT. Regulation of reactionary dentine formation. J Dent Res. 2018; 97 (4): 416-422.

  7. Zaugg LK, Banu A, Walther AR, Chandrasekaran D, Babb RC, Salzlechner C et al. Translation approach for dentine regeneration using GSK-3 antagonists. J Dent Res. 2020; 99 (5): 544-551.

  8. Rao AC, Venkatesh KV, Nandini V, Sihivahanan D, Alamoudi A, Bahammam HA et al. Evaluating the effect of tideglusib-loaded bioactive glass nanoparticles as a potential dentine regenerative material. Materials (Basel). 2022; 15 (13): 4567.

  9. Hanna S, Aly R, Eldeen GN, Adanero-Velasco A, Pérez-Alfayate R. Small molecule GSK-3 inhibitors safely promote the proliferation and viability of human dental pulp stem cells-in vitro. Biomedicines. 2023; 11 (2): 542.

  10. Regeneración y biomimética del esmalte
    La tendencia actual se dirige hacia la remineralización biomimética basada en péptidos autoensamblables, proteínas derivadas de amelogeninas y nanocristales de hidroxiapatita. Aunque la regeneración completa del esmalte sigue siendo un desafío biológico, estas revisiones son fundamentales:
    10. Kirkham J, Firth A, Vernals D, Boden N, Robinson C, Shore RC et al. Self-assembling peptide scaffolds promote enamel remineralization. J Dent Res. 2007; 86 (5): 426-430.

  11. Fan Y, Sun Z, Moradian-Oldak J. Controlled remineralization of enamel in the presence of amelogenin and fluoride. Biomaterials. 2009; 30 (4): 478-483.

  12. Elsharkawy S, Al-Jawad M. Protein and peptide-based biomimetic remineralization of dental enamel. Front Physiol. 2018; 9: 316.

  13. Pandya M, Diekwisch TGH. Enamel biomimetics-fiction or future of dentistry. Int J Oral Sci. 2019; 11 (1): 8.

  14. Hidroxiapatita derivada de orina (Urine-Derived Hydroxyapatite)
    Aunque todavía no existe una aplicación odontológica clínica consolidada, la hidroxiapatita obtenida a partir de fosfatos recuperados de la orina se perfila como una fuente sostenible para injertos óseos y biomateriales regenerativos. Esta es una línea emergente dentro de la bioeconomía circular aplicada a biomateriales:
    14. Randall DG, Krahenbühl M, Kopping I, Larsen TA, Udert KM. A novel approach for stabilizing fresh urine by calcium hydroxide addition. Water Res. 2016; 95: 361-369.

  15. Ohtake H, Tsuneda S. Phosphorus recovery and recycling. Springer; 2019.

  16. Huang YZ, He T, Cui J, Jiang YL, Zeng JF, Zhang WQ et al. Urine-derived stem cells for regenerative medicine: basic biology, applications, and challenges. Tissue Eng Part B Rev. 2022; 28 (5): 978-994. doi: 10.1089/ten.teb.2021.0142.

  17. Células madre y regeneración del complejo dentino-pulpar
    17. Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A. 2000; 97 (25): 13625-13630.

  18. Nakashima M, Iohara K. Regeneration of dental pulp by stem cells. Adv Dent Res. 2011; 23 (3): 313-319.

  19. Huang GT. Dental pulp and dentin tissue engineering and regeneration: advancement and challenge. Front Biosci (Elite Ed). 2011; 3 (2): 788-800.

  20. Iohara K, Imabayashi K, Ishizaka R, Watanabe A, Nabekura J, Ito M et al. Complete pulp regeneration after pulpectomy by transplantation of CD105+ stem cells with stromal cell-derived factor-1. Tissue Eng Part A. 2011; 17 (15-16): 1911-1920.




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