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2026, Number P5

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Acta Med 2026; 24 (P5)

Impact of intravenous tranexamic acid on blood loss and hemoglobin decrease in 1-3 level posterior lumbar fusion at the ISSSTE Regional Hospital “General Ignacio Zaragoza”

Braña RK, Cueva CMJF, Hernández RAK, Martínez APA, Vázquez TCF

Language: Spanish
References: 16
Page: 528-532
PDF size: 492.22 Kb.


ABSTRACT

Introducticon: tranexamic acid (TXA) has been incorporated into orthopedic surgery to reduce perioperative blood loss and transfusion requirements. Its efficacy and safety in posterior lumbar fusion remain under debate. The primary research question was whether intravenous TXA reduces blood loss and hemoglobin decrease in this procedure. Material and methods: retrospective study of 136 patients who underwent 1- to 3-level posterior lumbar fusion between March 2022 and December 2024 at a tertiary referral center. Sixty patients received intravenous TXA (15 mg/kg bolus followed by a 1 mg/kg/h infusion), and 76 did not. Demographics, intraoperative blood loss, hemoglobin decrease, transfusion, and complications were analyzed. Results: mean age was 59.9 ± 13.7 years, with female predominance (66.9%). The TXA group had significantly lower blood loss (629 ± 100 vs 802 ± 201 mL; p ‹ 0.0001) and a smaller decrease in hemoglobin (1.66 ± 0.36 vs 1.99 ± 0.58 g/dL; p = 0.0002). The proportion of transfused patients was markedly lower with TXA (21.7 vs 63.2%; p ‹ 0. 0001). No thrombotic or infectious complications occurred. Conclusions: intravenous TXA was associated with reduced blood loss, lower hemoglobin decline, and lower transfusion requirements in posterior lumbar fusion, with no complications observed in this cohort.


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