Serious gastroesophageal reflux associated to a Gastrointestinal Stromal Tumor (GIST). A case report

Gaby Alarcón Jarsún; Alberto Chousleb Kalach; Ariel Shuchleib Cung; Samuel Shuchleib Chaba

2007, Number 3

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Rev Mex Cir Endoscop 2007; 8 (3)

Serious gastroesophageal reflux associated to a Gastrointestinal Stromal Tumor (GIST). A case report

Alarcón JG, Chousleb KA, Shuchleib CA, Shuchleib CS

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Language: Spanish
References: 15
Page: 141-147
PDF size: 297.18 Kb.

ABSTRACT

Gastrointestinal stromal tumors (GISTs), have their origin in the interstitial cells of Cajal. In 90-95% of the patients, this disease is related to a KIT mutation (tyrosin-kinases receptor) that is demonstrated by immunohistochemical analysis. The identification of antigen CD 117 and CD 34 gives a distinctive cellular characteristic to these tumors. The incidence is low, approximately 14.5 by million annually. The most frequent affected organs are the stomach (60-70%), small bowel (20-30%), colon and rectum (10%). The majority are sporadic and solitary tumors (primary), the average age of presentation is of 50-60 years. Common symptoms are abdominal pain, gastrointestinal bleeding or palpable abdominal mass, however, most patients are asymptomatic and the lesions are discovered incidentally for other reasons. Surgical resection has been the only effective therapeutic modality. Case report, female, 67 years old, symptoms of severe gastroesophageal reflux, and during an endoscopy, a gastric compression was noted, an abdominal CT scan demonstrates a gastric tumor of approx 7 cm, between antrum and duodenum. Laparoscopic Nissen fundoplication and hiatal repair was done and at the same time a complete tumor resection from the gastric wall. Without any complication. Histopathologic report a complete resection and confirm the diagnosis of stromal gastric tumor intermediate risk CD 117 (+) CD 34 (+).

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