Hop GK, Carrera GE, González FV, Pérez EJ, Soriano RJ

Language: Spanish
References: 31
Page: 26-31
PDF size: 181.83 Kb.

ABSTRACT

Hereditary nonpolyposis colorectal cancer (HNPCC)was described in the 60’s by Henry T. Lynch and represent 3 to 5% of colon cancer; 70% of all families with the disease have mutations of germinal lineage and mismatch repair system (MMR) and 90% have microsatellite instability. It is associated with cancer in other sites, like gastric, endometrium, pancreatic, ovary and skin. The diagnosis must be done before 45 years old; no sex predilection has been observed and affect more frequently proximal colon and rectum. The clinical manifestations are the same than in usual colon cancer. We report 8 cases of hereditary nonpolyposis colorectal cancer in autopsy material seen in a 9 years period review; that represent 0.1% of all autopsy material during this period. Five female and 3 male, the mild age was 32.8 years old, 6 cases were located in left colon including rectum, and 2 cases in right colon. All cases have first or second degree relatives with carcinoma.

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