Gutiérrez-Vega R, Higuera-Hidalgo FR, Amancio-Chasin O

Language: Spanish
References: 20
Page: 83-87
PDF size: 92.58 Kb.

ABSTRACT

Purpose: Evaluate the utility of parecoxib and meloxicam, two selective COX 2 inhibitors, to prevent the formation of postsurgical adhesions in rats. Method: In animal model of peritoneal sepsis, by tie and punction of ceacum; in the postoperative they were randomly assigned in 3 groups: I control, II meloxicam, III parecoxib. The treatment was administered during ten days. The number of adhesions by group was identified. Results were studied with parametric ANOVA test. Results: There were fewer adhesions in groups treated with meloxicam and parecoxib, which was more evident in group treated with parecoxib. The total of adhesions by group was: control, 53 adhesions; meloxicam 38 adhesions and parecoxib 31 adhesions. The statistical analysis did not identify statistical differences between the groups. Conclusions: The administration of inhibitors of cyclooxygenase 2 should be evaluated with a significant sample to validate its possible therapeutic utility; as well as to study its effect on the gastrointestinal healing.

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