Ramírez CFJ, Acosta PLE, Red SRG, Sánchez SS

Language: Spanish
References: 6
Page: 116-119
PDF size: 145.75 Kb.

ABSTRACT

Introduction: Gastrointestinal stromal tumors (GIST) are rare cancers affecting digestive tract Cajal´s cells. Genetically, there are mutations of the surface cell´s proteins or tirosine-kinase receptors named KIT. Diagnosis is made using immunohistochemistry and a KIT or CD117 expression kit. 55% of the cases are of the digestive tract. The treatment is surgical to remove the tumoral mass followed with Imatinib mesylate as guided therapy with expected high response rates. Case report: 36 years old, female, with a history of in situ cervical cancer, and a 8 kg weight loss. She is seen after a two week history of epigastric pain. The endoscopy study showed an ulcerated lesion in the fundus. The biopsy results reported GIST, the CT Scan showed a gastric fundal neoplasm with hepatic metastasic lesions. We performed a radical extended gastrectomy with a splenectomy and distal pancreatectomy. The final histopathology results reported a gastric stromal tumor measuring 11.5 x 7 cm in size with free margins. The patient evolved well with an adequate response to Imatinib Mesylate. The aim of this case report is to demonstrate that an aggressive and mutidisciplinary approach in these types of patients improves survival even in the presence of metastatic disease.

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