Reséndiz MMA, Velázquez GG, Pérez EJ, Chávez ML, Olvera RJE

Language: Spanish
References: 9
Page: 222-227
PDF size: 494.11 Kb.

ABSTRACT

Background: Frequency of cryptococcosis, a mycotic disease that mostly affects central nervous system, has risen since 1980 decade, mainly as opportunistic infection in patients with AIDS. Objective: To review autopsies practiced in Hospital General de México since 1980 till 2003, and describe findings and review literature. Material and method: Descriptive study to review cerebral cryptococcosis cases characteristics in 17,431 autopsies practiced at pathology unit in Hospital General de Mexico from 1980 to 2003. Age group frequency, main clinical manifestations, evolution time, HIV serology, treatment, risk factors, immunosuppression related diseases, death causes, and neuropathological injuries findings were analyzed. Results: Twenty-nine cases with cerebral cryptococcosis. Mean age was 41 years old (16 to 83); 18 (62.1%) appearing between third to fifth decade of live; 18 (62%) were male and 11 (38%) female, with a relation of 1.7:1. Three cases had unspecific symptoms at the ad mission and diagnose was an autopsy finding. All of them with cryptococcosis, and without cryptoccocoma. Fourteen cases (48%) had systemic cryptococcosis with subacute evolution and poor response to amfotericine B treatment. Conclusions: Central nervous system cryptococcosis is the second opportunistic infection cause in HIV/AIDS patients. Meningeal condition is the most frequent in Mexico.

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