Bueno NA, Avila LA, Espinoza VJ, Alfaro RA, González PR

Language: Spanish
References: 9
Page: 16-18
PDF size: 55.05 Kb.

ABSTRACT

Mamalian’s vocal activity has a complex control at the cerebral level. In this context, brain injury one of the first fact to lead to aphasia in man. Thus, it is necessary to develop some animal models focused to study the vocal activity. In this work, we assesed such activity after the carotid occlusion in the guinea pig, as a natural brain damage model.
According to one non-corelated experimental design, it was used 15 male young guinea pigs (5 days old) allocated in 4 groups: without quirurgical intervention (control), quirurgical intervention without carotid occlusion (sham), quirurgical intervention and carotid occlusion during 5 minutes (Group 1) and quirurgical intervention and carotid occlusion during 10 minutes (Group 2). After interventions, number of vocalizations in 3 minutes were recorded. A non-corelated ANOVA analysis and a pos-hoc tukey test were used in order to compare groups (a£ 0.05). Results showed increase of vocal activity in animals of group 1 while in animals of group 2 such activity decreased. Additionally, in the last group it was observed that sequelae seems to that observed in humans and a ligthly trend to the functional recovery.
Such results can be explained in the basis of the role of the glutamatergic activity during ischaemia. The study of this damage could to contribute in the development of an animal model of aphasia.

REFERENCES

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