2004, Number 2
Comprative study: ciprofloxacin vs. neomicyn-polymyxinfluocinolone otic, administered in the ear in chronic otitis media with consequences
Arias-Mora JM, Herrera-Ortiz A, Castillo-Gaxiola BO
Full text
Language: Spanish
References: 11
Page: 31-34
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ABSTRACT
Patients with chronic otitis media need surgical treatment, and the ear must be free of any infectious process before surgery. Frequently, we find bacteria like P. aeruginosa and S. aureus that can be contended with the use of topical antimicrobials that do not have ototoxic effects. To compare the efficacy of the otic suspension of ciprofloxacin vs. neomicyn-polimyxin-fluocinolone in the treatment of chronic otitis media with tympanic perforation, and to identify the common pathogens, we carried out a prospective, comparative, double blind, clinical assay. We studied 60 patients consecutively with chronic otitis media with tympanic perforation who were divided into two groups with 30 patients each one. The treatment was assigned in an alleatory fashion: in group I we used ciprofloxacin suspension at 0.3%, and in group II we used suspension of neomicyn-polimyxin-fluocinolone, in both cases with three doses per day during ten days. All patients were older than 18. Before starting the treatment we practiced ear secretion cultures in each patient. In both groups the treatment was effective. Only one patient from group II had a positive culture after the treatment. Another patient had otic itching and the treatment was immediately discontinued. The most common pathogen identified was P. aeuruginosa. In conclusion, the otic suspension of ciprofloxacin is an effective treatment for chronic otitis media with otorrhea; it is similar in efficacy to otic suspension of neomycin-polimyxin-fluocinolone, but with fewer risks.REFERENCES