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Ginecología y Obstetricia de México

Federación Mexicana de Ginecología y Obstetricia, A.C.
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2009, Number 09

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Ginecol Obstet Mex 2009; 77 (09)

Pregnancy after conservative management of endometrial cancer

Fuentes DM, Arteaga GAC, Moreno VE, Aranda FCE
Full text How to cite this article

Language: Spanish
References: 6
Page: 419-422
PDF size: 209.88 Kb.


Key words:

pregnancy, endometrial cancer, infertility, obesity, nulliparity.

ABSTRACT

Objective: To show the reproductive future of a case of endometrial cancer with conservative management.
Material and methods: a case report and literature review. 31 years old woman, with a history of infertility of three years and abnormal uterine bleeding of one year, diagnosed with well differentiated endometrial adenocarcinoma IA GI. Treatment was initiated with 500 mg of progesterone three times a week for 6 months, after an endometrial curettage reporting healthy endometrium, pregnancy was achieved with homologous artificial insemination after hysteroscopy and directed biopsy with laparoscopic control by assisted reproduction service.
Results: Exploratory laparotomy and cesarean section was performed at 38 weeks of pregnancy, giving a 3.340 g weight male with Apgar score 9/9. A review of abdominal cavity and an obstetric curettage were performed. Biopsies were taken from slides and peritoneal lavage,Neoplastic changes were not reported by pathology.
Conclusions: Endometrial cancer is common in adult women and is increasingly affecting young women, associated with infertility, obesity and nulliparity. The treatment of choice: total hysterectomy with bilateral salpingooforectomy. The prognosis in well-differentiated early, and infertility, permits conservative management based on progestins, with good results, low recurrence rate and preserving fertility.


REFERENCES

  1. Dirección General de Estadística, Secretaría de Salud. Compendio del Registro Histopatológico de Neoplasias. México: DGE-SSA, 2003;pp:7-15.

  2. Torres LA, Hernández F, Hernández N, Román B, y col. Cáncer de endometrio. Estado actual de frecuencia por estadios y resultados del tratamiento en el Hospital General de México. Cancerología 2004;4:92-96.

  3. FIGO staging for corpus cancer. Br J Obstet Gynaecol 1992;5:440.

  4. Brinton L, Berman M, Twiggs L, et al. Reproductive, menstrual, and medical risk factor for endometrial cancer: results from a case-control study. Am J Obstet Gynecol 1992;167:1317-25.

  5. Boruban M, Altundag K, Kilic G, Blanksetein J. From endometrial hyperplasia to endometrial cancer: insight into the biology and possible medical prevent measure. Europ J Cancer Prevent 2008;17:133-38.

  6. Yamazawa K, Hiria M, Fujito A, Hirokata N, Terauchi F, et al. Fertility preserving treatment with progestin, and pathological criteria to predict responses, in young woman with endometrial cancer. Human Reprod 2007;22:1953-58.




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Ginecol Obstet Mex. 2009;77