This journal only 2010, Number 4 Cir Gen 2010; 32 (4) Hypothyroidism secondary to post-hemithyroidectomy performed to treat benign disease of the thyroid Basurto-Kuba EOP, Hurtado-Reynoso MA, Montes de Oca-Durán E, Pulido-Cejudo A, Ortiz-Higareda V, Hurtado-López LM Full text How to cite this article Language: Spanish References: 10 Page: 214-216 PDF size: 161.32 Kb. Key words: Thyroidectomy, lobectomy, hypothyroidism. ABSTRACT Objective: To know the prevalence and the predisposing diagnosis for hypothyroidism following postthyroidectomy for benign thyroid disease. Setting: Thyroid clinic. General Hospital of México (third level health care center). Design: Cohort study. Statistical analysis: Central tendency measures and Chi square. Patients and methods: Patients subjected to hemithyroidectomy plus isthmectomy due to benign thyroid disease from January 2000 to December 2009, who were euthyroid in the pre-operative period (TSH › 0.4 and ‹ 4.0 μUI/ml) and with the contralateral lobule macroscopically healthy. Assessed variables were: age, gender, post-operative levels of thyroid stimulating hormone (TSH), time of hypothyroidism development and definitive histopathological report. Results: Hundred-seventy-four patients were followed, 11 (6.4%) were men with an average age of 42 years (23 to 69 years) and 163 (93.6%) women, average age of 43 years (18 to 81 years). Final histopathological diagnoses were: 28 folicular adenomas (FA), 10 adenomatous colloid goiter (ACG), 119 nodular colloid goiter (NCG), 17 autoimmune thyroiditis (AT). Hypothyroidism was developed by 59 (33.9%) patients, their diagnoses were: 9 (15.2%) FA, 3 (5%) ACG, 32 (54.2%) NCG, and 15 (25.4%) AT. According to the definite diagnosis, hypothyroidism presented in FA (32.1%), ACG (30%), NCG (26.8%), and AT (88.2%). We compared the hypothyroidism prevalence among the different diagnosis and only AT revealed a statistical difference in favor of hypothyroidism (P ‹ 0.05); 86.4% of patients developed hypothyroidism during the first 6 months, the rest during the second post-operative semester, with the exception of one AT case that developed it 24 months after surgery. Conclusion: Prevalence of hypothyroidism secondary to hemi-thyroidectomy plus isthmectomy due to benign thyroid disease is of 33.9%. AT is a predisposing factor; hypothyroidism presented mostly during the first 6 post-surgery months. REFERENCES Su SY, Grodski S, Serpell JW. Hypothyroidism following hemithyroidectomy: a retrospective review. Ann Surg 2009; 250: 991-994. Sinard RJ, Tobin EJ, Massaferri EL, Hodgson SE, Young DC, Kunz AL, et al. Hypothyroidism after treatment for nonthyroid head and neck cancer. Arch Otolaryngol Head Neck Surg 2000; 126: 652-657. Alba M, Fintini D, Lovicu RM, Paragliola RM, Papi G, Rota CA, et al. Levothyroxine therapy in preventing nodular recurrence after hemithyroidectomy: a retrospective study. J Endocrinol Invest 2009; 32: 330-334. Wormald R, Sheahan P, Rowley S, Rizkalla H, Toner M, Timon C. Hemithyroidectomy for benign thyroid disease: who needs follow-up for hypothyroidism. Clin Otolaryngol 2008; 33: 587-591. Vaiman M, Nagibin A, Hagag P, Kessler A, Gavriel H. Hypothyroidism following partial thyroidectomy. Otolaryngol Head Neck Surg 2008; 138: 98-100. Miccoli P, Antonelli A, Iacconi P, Alberti B, Gambuzza C, Baschieri L. Prospective, randomized, double-blind study about effectiveness of levothyroxine suppressive therapy in prevention of recurrence after operation: result at the third year of follow-up. Surgery 1993; 114: 1097-1102. Piper HG, Bugis SP, Wilkins GE, Walker BA, Wiseman S, Baliski CR. Detecting and defining hypothyroidism after hemithyroidectomy. Am J Surg 2005; 189: 587-591. Seiberling KA, Dutra JC, Bajaramovic S. Hypothyroidism followinghemithyroidectomy for benign nontoxic thyroid disease. Ear Nose Throat J 2007; 86: 295-299. Buchanan MA, Lee D. Thyroid auto-antibodies, lymphocytic infiltration and the development of postoperative hypothyroidism following hemithyroidectomy for non-toxic nodular goitre. J R Coll Surg Edinb 2001; 46: 86-90. Miller FR, Paulson D, Prihoda TJ, Otto RA. Risk factors for the development of hypothyroidism after hemithyroidectomy. Arch Otolaryngol Head Neck Surg 2006; 132: 36-38.