Basurto-Kuba EOP, Hurtado-Reynoso MA, Montes de Oca-Durán E, Pulido-Cejudo A, Ortiz-Higareda V, Hurtado-López LM

Language: Spanish
References: 10
Page: 214-216
PDF size: 161.32 Kb.

ABSTRACT

Objective: To know the prevalence and the predisposing diagnosis for hypothyroidism following postthyroidectomy for benign thyroid disease.
Setting: Thyroid clinic. General Hospital of México (third level health care center).
Design: Cohort study. Statistical analysis: Central tendency measures and Chi square.
Patients and methods: Patients subjected to hemithyroidectomy plus isthmectomy due to benign thyroid disease from January 2000 to December 2009, who were euthyroid in the pre-operative period (TSH › 0.4 and ‹ 4.0 μUI/ml) and with the contralateral lobule macroscopically healthy. Assessed variables were: age, gender, post-operative levels of thyroid stimulating hormone (TSH), time of hypothyroidism development and definitive histopathological report.
Results: Hundred-seventy-four patients were followed, 11 (6.4%) were men with an average age of 42 years (23 to 69 years) and 163 (93.6%) women, average age of 43 years (18 to 81 years). Final histopathological diagnoses were: 28 folicular adenomas (FA), 10 adenomatous colloid goiter (ACG), 119 nodular colloid goiter (NCG), 17 autoimmune thyroiditis (AT). Hypothyroidism was developed by 59 (33.9%) patients, their diagnoses were: 9 (15.2%) FA, 3 (5%) ACG, 32 (54.2%) NCG, and 15 (25.4%) AT. According to the definite diagnosis, hypothyroidism presented in FA (32.1%), ACG (30%), NCG (26.8%), and AT (88.2%). We compared the hypothyroidism prevalence among the different diagnosis and only AT revealed a statistical difference in favor of hypothyroidism (P ‹ 0.05); 86.4% of patients developed hypothyroidism during the first 6 months, the rest during the second post-operative semester, with the exception of one AT case that developed it 24 months after surgery.
Conclusion: Prevalence of hypothyroidism secondary to hemi-thyroidectomy plus isthmectomy due to benign thyroid disease is of 33.9%. AT is a predisposing factor; hypothyroidism presented mostly during the first 6 post-surgery months.

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