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2011, Number 1

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Gac Med Mex 2011; 147 (1)

Gastric cancer: genetic and molecular abnormalities

Torres-Jasso JH, Sánchez-López JY
Full text How to cite this article

Language: Spanish
References: 4
Page: 72-73
PDF size: 72.89 Kb.


Key words:

Gastric cancer, Genetic and molecular alterations, Mutation.

ABSTRACT

In this work, the genetic and molecular alterations involved in gastric carcinogenesis are shown; the affected genes are those that encoded for matrix metalloproteinases, cell growth factors and receptors, oncogenes, tumor suppressors, DNA repair and cell adhesion molecule genes, cell cycle regulators and others related to metastasis, as well as lost of heterozygosity in chromosomal regions.


REFERENCES

  1. Milne AN, Carneiro F, O’Morain C, Offerhaus GJA. Nature meets nurture: molecular genetics of gastric cancer. Hum Genet. 2009;126:615-28.

  2. Okayama H, Kumamoto K, Saitou K, et al. CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer. Oncol Rep. 2009;4:745-55.

  3. Smith MG, Hold GL, Tahara E, El-Omar EM. Cellular and molecular aspects of gastric cancer. World J Gastroenterol. 2006;12(19):2979-90.

  4. Tamura G. Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer. World J Gastroenterol. 2006;12(2):192-8.




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C?MO CITAR (Vancouver)

Gac Med Mex. 2011;147