Cornejo AJR, Ramírez RA

Language: Spanish
References: 7
Page: 127-133
PDF size: 159.99 Kb.

ABSTRACT

INTRODUCTION. In Intensive Care Units, bacterial resistance accounts for a large incidence, as specific clinical settings appear to the development of multidrug resistant pathogens.
OBJECTIVE. To determine the proportion of bacterial susceptibility to antimicrobial agents in the Adults Intensive Care Unit (AICU).
PATIENTS AND METHODS. A retrospective, observational and transversal study was made in the Hospital de Alta Especialidad Christus Muguerza. We analyzed all the cultures with positive bacterial isolates, obtained from January 1^st, 2010 to June 30^th, 2011, of 18 years old and older patients admitted to the AICU for any cause. We calculated frequency and proportion for specific antimicrobial susceptibility and resistance for each bacterial strain, presenting only those antimicrobials recommended by the CLSI for each bacterial family using an isolation and patient based algorithms.
RESULTS. We analyzed a total of 361 isolations, documenting a total of 28 bacterial species, the more frequent were Pseudomonas aeruginosa, Acinetobacter baumanii, Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis and Klebsiella pneumonia. The susceptibility analysis for each bacterial strain is detailed forward. We detected ESBL-producing Escherichia coli in 22% of the total samples, ESBL-producing Pseudomonas aeruginosa in 64% of the total strains analyzed with an XDR resistance pattern, Acinetobacter baumanii, already an XDR strain, with tendency to be a PDR, and MRSA with a phenotypic resistance pattern of a hospital acquired strain with XDR tendency, but still susceptible to the recommended first line antimicrobials in the management of associated infections.
CONCLUSIONS. The isolation of the ESKAPE pathogens are a continuous problem in the Intensive Care Units, as development of XDR and PDR are a real challenge in the treatment of this infections.

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