Ramírez-Luna MÁ, Zepeda-Gómez S, Chávez-Tapia NC, Téllez-Ávila FI

Language: English
References: 11
Page: 11-14
PDF size: 50.38 Kb.

ABSTRACT

Background and aim. The correct approach and treatment in a patient with a pancreatic lesion detected by imaging is not easy. Recently, the endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) biopsy is becoming a useful tool. The aim of the study is to evaluate the diagnostic yield and therapeutic impact of EUS-FNA in pancreatic lesions. Methods. Fifty-three patients with focal pancreatic lesions underwent EUS-FNA from March 2005 to March 2006. The final diagnosis was confirmed by the histological analysis from the surgical specimen and/or clinical follow-up for at least 6 months. Results.Fifty-two patients were evaluated. Forty-seven useful samples for histological evaluation were obtained. Adequate samples were obtained in 83.3% (5/6) for lesions ‹ 20 mm, 100% (19/19) for lesions from 20 to ‹ 40 mm and 85.1% (23/ 27) for those ≥ 40 mm. To differentiate between benign/malignant disease the sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of EUS-FNA were 97.3% (95%CI: 84.9-99.1), 100% (95%CI: 66-100), 100% (95%CI: 88-100), 90% (95%CI: 57-96) and 97.8%, respectively. There was a change in the initial diagnosis in seven patients (14.8%). No complications were reported. Conclusions. EUS-FNA is a useful and safe method with high predictive values to differentiate between malignant and benign pancreatic lesions.

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