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Patología Revista Latinoamericana

2013, Number 1

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Patol Rev Latinoam 2013; 51 (1)

Dural plasmacytoma as first manifestation of multiple myeloma. Report of four cases and review of the literature

Vicuña-González RM, Rivera-Salgado MI, Pasquel-García-Velarde PM, Peter Grube-Pagola

Language: Spanish
References: 18
Page: 3-12
PDF size: 747.32 Kb.


ABSTRACT

Solitary craneal plasmacytoma may involve bones of vault or base. Rarely cerebral parenchyma or meninges may be affected. In approximately 20-30 per cent of the cases cranial plasmacytoma becomes multiple myeloma and this is a more frequent event when the lesion is bone seated. The evolution to myeloma may occur several years after diagnosis. The main differential diagnosis in dural cases is lymphoplasmacyte-rich meningioma.
We report four cases of plasmacytoma involving dura and cranial bone; they were three men and one woman, with age between 55 and 73 years. The tumors were very large and the clinical and imaging diagnosis was meningioma. Extension studies performed after surgical excision of tumors disclosed multiple myeloma in all patients. The follow up time ranged from 12 to 55 months. Three patients are alive with disease and the other is lost for follow up. When a cranial plasmacytoma presents as first manifestation is mandatory a search for multiple myeloma because the therapy and prognosis are quite different in both cases.


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