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2013, Number 2

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Rev Cubana Farm 2013; 47 (2)

Design of a regenerative chitin cream for use after sun tanning

Pérez RP, Nieto AOM, Bilbao RO, López TA, González CL

Language: Spanish
References: 12
Page: 239-251
PDF size: 464.91 Kb.


ABSTRACT

Introduction: after taking the sun, it is indispensable to repair the skin affected by harmful rays. The cosmeceuticals for use after sunbath have antinflammatory, relaxing, hydrating, soothing and regenerative elements of the epithelium, which prevent or mitigate the feeling of pain, tautness, burning and rash.
Objective: to develop a regenerative chitin cream to be used after sun tanning, with due quality to repair and hydrate the skin.
Methods: two experimental designs 22 (F1 and F2) were created in which glycerin and propilenglycol were used as humectants respectively. Ph and extensibility were measured as variables in addition to analyzing the psychophysiological properties, the shearing tension and the centrifugation tests as well as the temperature impact during 60 days.
Results: there were no significant differences between propilenglycol and glycerin whereas the incidence of cetyl alcohol in extensibility and pH values was noticeable. The best variant was the no. 1 in the F2 design in which the cetyl alcohol was found at 4 % and the propilenglycol at 3 %. The pH value was 7.05 ± 0.00; the extensibility was 68.15 ± 1.51 and the shear tension was 1.93 ± 0.01. The psychophysiological properties were satisfactory and there was no creaming or coalescence.
Conclusions: it may be considered that, according to the measurements made in the evaluated period of time, the characteristics are satisfactory for the prepared creams; being variant I of the F2 design the least expensive. The physical stability of formulations undergoing tests of centrifugation and temperature impact indicates good compatibility between the studied polymer and the excipients.


REFERENCES

  1. Almirall I, González HM. Fernández T, Diaz M. Desarrollo de una crema cosmética con extracto de Spirulina platensis cubana. Rev Cubana Farm [Internet]. 2005 [citado 21 Nov 2012];39(3). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034- 75152005000300008&lng=es

  2. Piquero J. Cosmética con ética. GCI Latinoamérica (Sao Paulo). 2002;1:19-22.

  3. Colectivo de autores. Biopolímeros en la Industria Cosmética. Cosmetics & Toiletries Latinoamérica (Sao Paulo). 2010 Jan.;3:19-22.

  4. Balassa LL, Pruden JF. Applications of Chitin and Chitosan in wound healing acceleration. In: Muzzarelli. Proc. I Conf. on chitin and chitosan. New York: Academic Press; 1998. p. 296-315.

  5. Henriques R, Nieto OM. Método para la obtención de quitina suficientemente pura. Patente cubana No. 20760- 01:17:08. 1980.

  6. Allan G, Altman L, Besinger R, Gosh D, Hirabayashi Y, Neogi A, et al. Biomedical applications of chitin and chitosan. In: Zikakis JP. Chitin and Chitosan related enzymes. New York: Academic Press; 1984. p. 119-33,

  7. Henriques RD, Nieto OM. Método para la obtención de quitina suficientemente pura. Patente cubana No. 20760- 01:17:08. 1980.

  8. Ugarte R. Tecnología de la producción de preparados farmacéuticos semisólidos. La Habana: Editorial Ciencia y Técnica; 1975.

  9. Iraizoz A, Bilbao O, Barrios, MA. Conferencias de tecnología farmacéutica II. La Habana: Enpes; 1990. p. 124.

  10. López Planes R. Diseño estadístico de experimentos. La Habana: UH; 1994.

  11. Faullí C. Tratado de Farmacia Galénica. Madrid: Ed. Luzaú; 2000.

  12. Olsen EO. Métodos ópticos de análisis. Barcelona: Reverté; 1990.




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