2013, Number 4
Betamethasone (sodium phosphate + acetate) prevents inflammation and trismus in retained lower third-molar surgery. Glucocorticoids in third-molar surgery
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ABSTRACTBackground: Retained third-molar surgery is a relatively common procedure in oral surgery. The most important consequences of this surgical procedure are pain, swelling, and trismus, all of which can be treated with both non-steroidal anti-inflammatory painkillers and steroidal anti-inflammatory drugs. Aim: To compare the efficacy of betamethasone to that of deflazacort in reducing inflammation and trismus in retained lower third-molar surgery. Material and methods: Two experimental groups were formed. Each was treated with either betamethasone or deflazacort prior to undergoing third-molar surgery. 11.4 mg of betamethasone was administered intramuscularly to 24 patients in a single dose; meanwhile, 21 others were orally administered 30 mg of deflazacort, in both cases one hour prior to surgery and then once daily for a period of seven days. Clinical inspection of extraoral tissues was performed to assess inflammation, whilst trismus was analyzed by measuring interincisal distance and comparing the changes that had taken place since day one. Results: None of the patients treated with betamethasone displayed any severe inflammation. 45.8% showed mild inflammation, 16.7% moderate inflammation, and 37.5% zero inflammation. All of the subjects treated with deflazacort showed varying degrees of inflammation: 52.4% mild, 42.8% moderate, and 4.8% severe. The χ2 test revealed significant differences between the two treatments in terms of both inflammation and trismus. The differences in trismus became apparent on the day after surgery only. The results showed no significant differences in terms of the duration of the inflammation. Conclusions: Treatment with betamethasone was found to have a greater anti-inflammatory effect than that of deflazacort, based on the statistically significant differences found; throughout the treatment, the same was true as regards the prevention of trismus.
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