Morales RE, Robaina JZ, Soriano TM, Benítez CY, Del Sol M, Marín PL

Language: Spanish
References: 16
Page:
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ABSTRACT

Introduccion: Schizophrenia is a mental disorder affecting world population, with a prevalence of 1% and inheritability to 80%. Cytogenetics and molecular investigations have identified a great number of chromosomal aberrations in patients with schizophrenia that equally involve both autosomic and sexual chromosomes. The purpose of this investigation was to identify aberrations with possible associated to schizophrenia.
Discussion: A descriptive and case study was carried out. The sample was conformed by one family composed by 11 members with records of mental illness. High-resolution cytogenetic techniques were used. We report on a family with three affected members, structural and numerical aberrations were identified.
Conclusion: The X chromosome aneuploidy in mosaic was the more frequent chromosomal alteration observed in the course of research. Due to their high frequency in this population we believe that regions implicated in chromosomal alterations should be further investigated as possible susceptibility locus to schizophrenia.

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