Sánchez GSA, Zapata CNP, Tolentino DM, Barbosa IA, Candelaria HM, Labardini MJR, Zamora SL, Alonso LAD, Rivas PE, Buendía GL, Damián YD, Ángel OC, Sámano SR, Morales RM, Schnaas L

Language: Spanish
References: 4
Page: 12-16
PDF size: 157.09 Kb.

ABSTRACT

Background: Apheresis allows to collect specific and high-quality blood components but changes serum calcium and magnesium concentrations due to citrate infusion. Aim: To compare pre and post-plateletpheresis serum levels of calcium (Ca), magnesium (Mg), zinc (Zn), copper (Cu) and parathyroid hormone (PTH) among donors. Materials and methods: Prospective study including 105 donors. Basal and post-procedure serum levels of PTH, Ca, Mg, Zn and Cu were measured by ion selective potentiometry, final dot, atomic absorption and solid phase two site chemoluminiscence. In case of adverse reactions a blood sample was drawn to analyze concentrations of such hormone and minerals. We intended to correlate both, diet and adverse reactions with levels of aforementioned elements. Statistical analysis included X2 and ANOVA. Protocol was approved by the ethical and research committee. Results: One hundred five donors (68 males and 37 females) were studied. PTH levels increased three-fold whereas Ca, Mg, Zn and Cu levels significantly decreased specially in women older than 30 years. Conclusions: Plateletpheresis induced a secondary hyperparathyroidism while Ca, Mg, Cu and Zn were chelated. These results urges us to assess the kinetics of these changes and to follow a cohort of donors with bone densitometry in order to assure that repetitive plateletpheresis does not become a long-term risk for osteopenia and osteoporosis.

REFERENCES

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3. Bueno JL. Do we really know the real risk of an apheresis donation? ISBT Science Series. 2007; 2: 68-74.

4. Bojórquez I, Mendoza M, Tolentino M et al. Risky alimentary conducts are not associated with micronutrients deficiencies in reproductive-age women in Mexico City. Arch Latinoam Nutr. 2010; 60: 64-69.