Flores-Uscanga KM, Álvarez-Hernández MD, Orosa-Fernández IP, Manríquez-Reyes M

Language: Spanish
References: 19
Page: 628-633
PDF size: 670.01 Kb.

ABSTRACT

The hypersensitivity drug síndrome is characterized by the triad of fever, rash and multiorgan involvement. This term encompasses different entities, that describe as common pattern a severe drug reaction; when combined with allopurinol intake has been called allopurinol hypersensitivity syndrome (AHS), with a reported mortality of up to 40% in cases with multiorgan involvement. The etiopathogenic of allopurinol hypersensitivity syndrome is not well-known, cutaneous presentation of these patients is variable the same as systemic manifestations. The diagnosis is established by the exposure to the drug, clinical, laboratory, and making differential diagnosis with other diseases. The therapeutic management so far includes suspension of the offending drug, supportive treatment and prevention of sepsis. We report the case of a 48-year-old male with chronic kidney disease, the patient was prescribed allopurinol, and four weeks after starting treatment had a severe drug reaction, which conditioned acute liver failure.

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