2013, Number 4
Course of pregnancy in chronic myelogenous leukemia patients given tyrosien kinase inhibitors
Da Costa O, Borrego M, Gil M, López J
Full text
Language: Spanish
References: 9
Page: 178-181
PDF size: 309.62 Kb.
ABSTRACT
Background: Tyrosine kinase Inhibitors (TKIs), constitute the treatment of choice of the CML, since that they achieve a higher response rate and have improved the life expectancy of this disease. Many female patients, are in reproductive age, in them it is recommended the use of contraceptive methods since to Imatinib demonstrated teratogenicity in animals and to the unknown safety profile of an inadvertent exposure during the embryogenesis to Nilotinib or Dasatinib. We described the pregnancy evolution, delivery and characteristics of the product of patients with CML diagnosis who have procreated on a planned or inadvertent way during the treatment with TKIs, who assist to consultation in the BMS (Caracas-Venezuela). All Medical reports of female gender treated with TKIs were reviewed by diagnose of CML in the BMS, and 9 females became pregnant during or after the TKI treatment. Six patients were in chronic phase, 2 in accelerated phase and 1 in blast crisis. Only 2 patients were in MMR at the moment of pregnancy. Five patients were receiving treatment with Imatinib, 1 with Nilotinib and 1 with Dasatinib. Only 2 patients were suspended the TKI treatment previous to the gestation (planned pregnancy). All patients who were not in CP, presented complications that required hospitalization. Every product has good health except the twins that lost their control visits.Discussion and conclusion. . Any product presented congenital malformation The patients with CML in chronic phase, well controlled with MMR at the pregnancy moment, had then good evolution, but those who were not in MMR, progressed in the postpartum period to blast crisis with fatal outcome. It is not recommended the use of TKIs during the conception period or in embryogenesis phase.
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