2013, Number 608
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Rev Med Cos Cen 2013; 70 (608)
Insulinoma
Picado LLN
Language: Spanish
References: 10
Page: 665-670
PDF size: 170.84 Kb.
ABSTRACT
Insulinoma is a rare
neuroendocrine tumor, with
an incidence of 4 per 1 million
persons with an average age
of presentation between 40-45
years; mainly women. Most
of them are benign; they are
frequently a part of multiple
endocrine neoplasia type 1; the
main clinical manifestations
are neuroglycopenic and
hypoglycemic symptons
including Whipple triad;
diagnosis is mainly made
with CT, MRI, endoscopic US
besides the measurement of
blood concentration of insulin,
peptide C and proinsuline;
surgical excision of the tumor is
the definite treatment.
Descriptores:
Insulinoma, tumores
neuroendocrinos, síndrome de
neoplasia endocrina múltiple
tipo 1, hipoglicemia, tríada de
Whipple, Diazóxido
REFERENCES
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Abood Gerard J., et al, The Surgical and Systemic Management of Neuroendocrine Tumors of the Pancreas, Surgical Clinics of North America, Volume 89, Issue 1, February 2009: 249-252
Jensen Robert T., Feldman: Sleisenger and Fordtran´s Gastrointestinal and Liver Disease, 9th ed. Chapter 32 Endocrine Tumors of the pancreas and Gastrointestinal tract, 2010: 491-498
Levy Michael J., et al, US-guided ethanol ablation of insulinomas: a new treatment option, Gastrointestinal Endoscopy, Volumen 75, Issue 1, January 2012, American Society for Gastrointestinal Endoscopy.
Nakakura Eric K., Islet Cell Carcinoma: Neuroendocrine Tumors of the Pancreas and Periampullary Region, Hematology/Oncology Clinics of North America, Volume 21, Issue 3, June 2007: 457-473
Saju Joseph, et al, Neuroendocrine Tumors : Current Recommendations for Diagnosis and Surgical Management, Endocrinology and Metabolism Clinics, Volumen 40, Issue 1, March 2011: 205-231
F. John Service, Hypoglycemia in adults without diabetes mellitus: Diagnostic approach, UptoDate, 2013
F. John Service, Insulinoma, Uptodate, 2012
White Matthew L., et al, Multiple Endocrine Neoplasia, Surgical Oncology Clinics of North America, Volume 17, Issue 2, April 2008: 439- 459
Zhao YP, et al, Surgical management of patients with insulinomas: Result of 292 cases in a single institution. Journal of surgical oncology, 01- Feb-2011; 103 (2):169-74
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