2014, Number 611
<< Back Next >>
Rev Med Cos Cen 2014; 71 (611)
Púrpura trombocitopénica inmunitaria
Acón RE
Language: Spanish
References: 10
Page: 509-514
PDF size: 216.15 Kb.
ABSTRACT
Immune thrombocytopenia
is an autoimmune mediated
condition that results from
antibody mediated destruction
of platelets and impaired
megakaryocyte platelet
production.(8)The dominant
clinical manifestation is
bleeding, which correlates
generally with severity of
the thrombocytopenia. Most
cases are considered primary,
without any underlying medical
problem, whereas others
are attributed to coexisting
conditions.(4)Management,
outcome, prognosis and
treatment are controversial
and require an individualized
approach and plan depending
upon the platelet count,
bleeding symptoms, lifestyle
and medication side effects.
REFERENCES
Boruchov, Donna; Gururangan, Sri et al. Multiagent induction and maintenance therapy for patients with refractory immune thrombocytopenic purpura (ITP). Blood 2007; 110(10): 3526-3531.
2. Cheng, Gregory. Eltrombopeg, a thrombopoietin-receptor agonist in the treatment of adult chronic immune thrombocytopenia: a review of efficacy and safety profile. Ther Adv Hematol. 2012 ; 3 (3): 155-164.
3. Cines, Douglas; Bussel, James. How I treat idiopathic thrombocytopenic purpura (ITP). Blood 2005; 106: 2244-2251.
4. Cines, Douglas; Bussel, James et al. The ITP syndrome pathogenic and clinical diversity. Blood 2009; 113 (26): 6511-6521.
5. Donato, Hugo; Cedola, Alejandra et al. Púrpura trombocitopénica inmunitaria. Guía de diagnóstico y tratamiento. Arch Argent Pediatr 2010; 108(2): 173-178.
6. Ghanima, Waleed; Godeau, Bertrand et al. How I treat immune thrombocytopenia: the choice between splenectomy or a medical therapy as a second line treatment. Blood 2012; 120: 960-969.
7. Ling, Yun; Qian, Xinyu et al. Combination therapy of rituximab and corticosteroids for patients with refractory chronic immune thrombocytopenic purpura: report of two cases. Contem Oncol (Pozn). 2013; 17(2): 222-224.
8. Neunert, Cindy. Current management of immune thrombocytopenia. American Society of Hematology Education Book. vol 2013 no 1 276-282.
9. Semple, John. ITP three R´s: regulation, routing, rituximab. Blood 2008; 112: 927-928.
10. Verdugo, Patricia; Kabalan, Paola et al. Guías Clínicas para el manejo del paciente pediátrico con trombocitopenia immune primaria. Rev Chil Pediatr 2011; 82 (4): 351- 357.
Full text