Corona-Hernández MA, Hernández-Rodríguez S, Rivera-Trujillo A

Language: Spanish
References: 19
Page: 190-195
PDF size: 438.04 Kb.

ABSTRACT

The non-Hodgkin’s anaplastic large T cells is a rare, aggressive with advanced disease entity. Extranodal involvement is seen in more than half of the cases; it is more frequent in bone and soft tissue. The non- Hodgkin’s lymphoma presented as spinal cord compression is rare and occurs in less than 5% of cases. In Mexico there are no previous reports of clinical cases of patients with anaplastic lymphoma with primary localization in spinal cord. We report the case of a patient with clinical manifestations of motor and sensory deficits in the lower extremities without systemic symptoms. MRI of thoracic spine showed spinal additional tumor in T3-T5 with spinal cord compression. The patient tumor resection was performed and histopathologic result was anaplastic large cell lymphoma in soft tissue spine ALK +, positive CD30, EMA, CD45, CD68 and vimentin. Patient received local radiotherapy and chemotherapy with MACOP scheme B. The post-treatment PET/CT showed no tumor activity. Clinically the patient is in complete remission with relieve of neurological manifestations.

REFERENCES

1. Sagaert X, De Wolf-Peeters C. Anaplastic large cell lymphoma. Current Diagnostic Pathology 2003;9:252-258.

2. Ferreri AJM, Govi S, Pileri SA, Savage KJ. Anaplastic large cell lymphoma, ALK-positive. Crit Rev Oncol/Hematol 2012;83:293-302.

3. Tsukada T, Ohno T, Tsuji K, Kita K, et al. Primary epidural non-Hodgkin’s lymphoma in clinical stage IEA presenting with paraplegia and showing complete recovery after combination therapy. Intern Med 1992;31:513-515.

4. Otter R, Gerrits WB, Sandt MM, Hermans J, Willemze R. Primary extranodal ando nodal non-Hodgkin’s lymphoma. A survey of a population-based registry. Eur J Cancer Clin Oncol 1989;25:1203-1210.

5. Salvati M, Cervoni L, Artico M, Raco A, et al. Primary spinal epidural non-Hodgkin’s lymphomas: A clinical study. Surg Neurol 1996;46:339-343.

6. Monnard V, Sun A, Epelbaum R, Poortmans P, et al. Primary spinal epidural lymphoma: patient’s profile, outcome, and prognostic factors: a multicenter Rare Cancer Network study. Int J Radiat Oncol Biol Phys 2006;65:817-823.

7. Kumar S, Wanchu A, Sharma A, et al. Spinal cord compression caused by anaplastic large cell lymphoma in an HIV infected individual. J Can Res Ther 2010;6:376-378.

8. Schmidt MA, Ramírez BD, Rome SM, Ramos CS. Fascitis eosinofílica asociada a un linfoma anaplásico de células grandes KI-1 CD-30 positivo. Presentación de un caso. Revista de Posgrado de la VIa Cátedra de Medicina 2002;120

9. Kelleher FC, McDermott R. The emerging pathogenic and therapeutic importance of the anaplastic lymphoma kinase gene. Eur J Cancer 2010;46:2357-2368.

10. Banharroch D, Meguerian-Bedoyan Z, Lamant L, et al. ALK positive lymphoma: a single disease with a broad spectrum of morphology. Blood 1998;91:2076-2084.

11. Falini B, Bigerna B, Fixxotti M, et al. ALK expression defines a distinct group of T/null lymphomas “ALK lymphomas” with a wide morphological spectrum. Am J Pathol 1998;153:875-886.

12. Foss HD, Anagnostopoylos I, Araujo I. Anaplastic large-cell lymphomas of T-cell and null-cell phenotype express cytotoxic molecules. Blood 1996;88:4005-4011.

13. Krenacs L, Wellmann A, Sorbara L. Cytotoxic cell antigen expression in anaplastic large cell lymphomas of T and null-cell type and Hodgkin’s disease: evidence for distinct cellular origin. Blood 1997;89:980-989.

14. Lamant L, Meggetto F, Al Saati T, et al. High incidence of t(2;5)(p23;q35) translocation in anaplastic large cell lymphoma and its lack of detection in Hodgkin’s disease. Comparison of cytogenetic analysis, reverse transcriptasepolymerase chain reaction, and P-80 immunostaining. Blood 1996;87:284-291.

15. Mason DY, Bastard C, Rimokh R, et al CD30-positive large cell lymphomas (‘Ki-1 lymphoma’) are associated with a chromosomal translocation involving 5q35. Br H Haematol 1990;74:161-168.

16. Carbone PP, Kaplan HS, Musshoff K. Report of the Committee on Hodgkin’s Disease Staging Classification. Cancer Res 1971;31:1860-1861.

17. Kako S, Izutsu K, Ota Y, et al. FDG-PET in T-cell and NK-cell neoplasms. Ann Oncol 2007;18:1685-1690.

18. Brugiéres L, Deley MC, Pacquement H, et al. CD30(+) anaplastic large-cell lymphoma in children: analysis of 82 patients enrolled in two consecutive studies of the French Society of Pediatric Oncology. Blood 1998;92:3591-3598.

19. Krieger G, Kreysing E, Kneba M. Anaplastic large cell lymphoma Hodgkin’s-like: a randomized trial of ABVD vs MACOP B with and without radiation therapy. Blood 1998;92:790-794.