Mora AM

Language: Spanish
References: 14
Page: 355-661
PDF size: 191.62 Kb.

ABSTRACT

SIRS is a set of systemic reactions that the body undertakes in order to deal with an aggressive stimulus against a tissue, manifested by an activation of inflammatory pathways to aggressive stimulus, which can be cause by bacterial, viral, parasitic, inflammatory or special situations in which the patient is exposed to the activation of these pathways like in the case of patients postoperatively, children, elderly, pregnant among other cases in which the immune response is not like the authors have described in the literature. In an exaggerated SIRS response to harmful stimuli, the fundamental intent of the inmunesistem is to deal the damaging stimulus and for microorganisms (when the cause is infectious), entirely destroy the offending agent, to restore bodily homeostasis. This in turn can damage even the same host tissue, causing release of pro-inflammatory mediators in large quantity, and oxygen free radicals and other harmful substances that end up driving the process to multiple organ failure (MOF) and finally to death. The diagnosis and treatment is complex and has not been described properly, but is determined criteria and protocols for the management of patients with SIRS in general, which has led to improved care and clinical management of these patients and their treatment and survival.

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