medigraphic.com
SPANISH

Anales de Otorrinolaringología Mexicana

Anales de Otorrinolaringología Mexicana
  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Instructions for authors        
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2015, Number 2

<< Back Next >>

Otorrinolaringología 2015; 60 (2)

Application of bevacizumab (Avastin®) in recurrent papilloma without laser KTP

Rangel-Chávez JJ, Espinosa-Martínez C, Rangel-Audelo R
Full text How to cite this article

Language: Spanish
References: 9
Page: 109-113
PDF size: 304.20 Kb.


Key words:

recurrent respiratory papillomatosis, treatment, potassium titanyl phosphate laser, bevacizumab.

ABSTRACT

Nowadays, recurrent respiratory papillomatosis does not have cure, treatment with photoangiolitic laser (KTP) is efficient, but does not avoid its recurrence. It has been initiated the adjuvant treatment with sublesional injections of antiangiogenic agent bevacizumab (Avastin®) as new therapeutic modality. In Mexico, there are little hospitalary units with availability of laser KTP, thus, patients are treated only with lesions resection. This paper reports a case of recurrent respiratory papillomatosis that received the treatment protocol of Voice Center of General Hospital of Massachusetts, administering intralesional bevacizumab (Avastin®) and thermoangiolisis with low-intensity bipolar coagulation, replacing the use and photoangiolitic effect of laser KTP.


REFERENCES

  1. Rosen CA, Woodson GE, Thompson JW, Hengesteg AP, Bradlow HL. Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis. Otolaryngol Head Neck Surg 1998:118:810-815.

  2. Snoeck R, Wellens W, Desloovere C, et al. Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine. J Med Virol I998;54:219-225.

  3. Strong MS, Vaughan CW, Cooperband SR, Hcaly GB, Clemente MA. Recurrent respiratory papillomatosis: management with the CO2 laser. Ann Otol Rhinol Laryngol 1976;85:508-516.

  4. El-Bitar MA, Zalzal GH. Powered instrumentation in the treatment of recurrent respiratory papillomatosis: an alternative to the carbon dioxide laser. Arch Otolaryngol Head Neck Surg 2002;128:425-428.

  5. Zeitels SM, Akst L, Burns JA, Hillman RE, et al. Office-based 532-nm pulsed KTP laser treatment of glottal papillomatosis and dysplasia. Ann Otol Rhinol Laryngol 2006:115:679- 685.

  6. Zeitels SM, Lopez-Guerra G, Burns JA, et al. Microlaryngoscopic and office-based injection of bevacizumab (Avastin) to enhance 532-nm pulsed KTP laser treatment of glottal papillomatosis. Ann Otol Rhinol Laryngol Suppl. 2009;201:1-13.

  7. Mackenzie M. Growths in the larynx. London: J & A Churchill, 1871.

  8. Hooper FH. On the treatment and recurrence of papilloma of the larynx (Thesis). Arch Laryngol 1882;3:334-343.

  9. Zeitels SM, Barbu AM, Landau-Zemer T, Lopez-Guerra G, et al. Local injection of bevacizumab (Avastin) and angiolytic KTP laser treatment of recurrent respiratory papillomatosis of the vocal folds: A prospective study. Ann Otol Rhinol Laryngol 2011:120:627-634.




2020     |     www.medigraphic.com

Mi perfil

C?MO CITAR (Vancouver)

Otorrinolaringología. 2015;60