medigraphic.com
SPANISH

Revista de la Facultad de Medicina UNAM

  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Instructions for authors        
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2016, Number 3

<< Back Next >>

Rev Fac Med UNAM 2016; 59 (3)

Apathetic hyperthyroidism in middle-aged patient. Case report and literature review

Briseño LP, Ceballos VJC, Rodríguez CZM, Téllez MLA, Mendoza ZV, MacGregor GJM
Full text How to cite this article

Language: Spanish
References: 19
Page: 22-26
PDF size: 290.32 Kb.


Key words:

Weight loss, vertigo, depression, apathetic hyperthyroidism.

ABSTRACT

Hyperthyroidism is a common condition that is easily recognized by its signs and symptoms. The apathetic hyperthyroidism is a form of presentation of hyperthyroidism without its characteristic signs and symptoms. The cardinal symptoms of apathetic hyperthyroidism are depression and apathy. The absence of classical signs and symptoms of hyperthyroidism delays the diagnosis and treatment of the disease, as it is often misdiagnosed as a primary psychiatric disorder. It is more common in elderly patients and is extremely rare in children and middle-age adults. We report the case of a middle-age woman with apathetic hyperthyroidism characterized by depression, dizziness, edema and weight loss without other clinical data of hyperthyroidism; she had been treated for two years for major depressive disorder. She had been studied by other specialties because of vertigo. The diagnosis was made after thyroid function tests were requested, and joined with clinical findings


REFERENCES

  1. Mandel SJ, Larsen PR, Davies TF. Capítulo 12. Thyrotoxicosis. En: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Textbook of Endocrinology. 12th ed. Philadelphia: Elsevier Saunders; 2011.

  2. Lahey FH. Apathetic thyroidism. Ann Surg. 1931;93:1026-30.

  3. Trivalle C, Doucet J, Chassagne P, Landrin I, Kadri N, Menard JF, et al. Differences in the signs and symptoms of hyperthyroidism in older and younger patients. J Am Geriatr Soc. 1996;44:50-3.

  4. Boelaert K, Torlinska B, Holder RL, Franklyn JA. Older subjects with hyperthyroidism present with a paucity of symptoms and signs: a large cross-sectional study. J Clin Endocrinol Metab. 2010;95:2715-26.

  5. McGee RR, Whittaker RL, Tullis IF. Apathetic thyroidism: review of the literature and report of four cases. Ann Intern Med. 1959;50:1418-32.

  6. Teeluckshingh S, Pendek R, Padfield PL. Apathetic thyrotoxicosis in adolescence. J Intern Med. 1991;229:543-4.

  7. Grewal RP. Apathetic hyperthyroidism in an adolescent. J Psychiatr Neurosci. 1993;18:276.

  8. Wagle AC, Wage SA, Patel AG. Apathetic form of thyrotoxicosis. Can J Psychiatry. 1998;43:747-8.

  9. Wu W, Sun Z, Yu J, Meng Q, Wang M, Miao J, et al. A clinical retrospective analysis of factor associated with apathetic hyperthyroidism. Pathobiology. 2010;77:46-51.

  10. Feroze M, May H. Apathetic thyrotoxicosis. Int J Clin Pract. 1997;51:332–3.

  11. Arnold BM, Casal G, Higgins HP. Apathetic thyrotoxicosis. CMAJ. 1974;111:957-8.

  12. Zefirova GS, Lebedev VV, Mirzoiants GG, Strokov IA. Apathetic form of thyrotoxicosis. Ter Arkh. 1986;58:112-4.

  13. Gaitonde DY, Kepchar J, Sartori R, Sarkar M. Painless thyroiditis presenting as apathetic hyperthyroidism in a young male. Mil Med. 2008;173:609-11.

  14. Weetman AP. Graves’ disease. N Engl J Med. 2000;343: 1236-48.

  15. Ross DS. Radioiodine therapy for hyperthyroidism. N Engl J Med. 2011;364:542-50.

  16. CENETEC. Diagnóstico y Tratamiento de la Enfermedad de Graves en mayores de 18 años. México: Secretaría de Salud; 2011.

  17. Bahn RS, Burch HB, Cooper DS, Garber JR, Greenlee MC, Klein I, et al. Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid. 2011;21:593-646.

  18. Bartalena L, Tanda ML. Graves’ ophthalmopathy. N Engl J Med. 2009;360:994-1001.

  19. Cooper DS. Antithyroid drugs. N Engl J Med. 2005;352: 905-17.




2020     |     www.medigraphic.com

Mi perfil

C?MO CITAR (Vancouver)

Rev Fac Med UNAM . 2016;59