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>Journals >El Residente >Year 2016, Issue 2

Cabrales-Escobar IE, Zermeño-González ML, Nava-Zavala AH, Rubio-Jurado B
Trombosis venosa profunda y tromboembolia pulmonar en pacientes con cáncer colorrectal
Residente 2016; 11 (2)

Language: Español
References: 56
Page: 60-70
PDF: 301.92 Kb.

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Since the publication of «Clinique Médicale de l’Hôtel-Dieu de Paris» by Trousseau in 1865, an important link between malignancy and hypercoagulable states has been established. Thrombosis is often diagnosed as the first clinical manifestation of a tumour and the second leading cause of death of patients with cancer. Moreover, various authors have demonstrated a significant correlation between the incidence of thromboembolic events and a worse prognosis of neoplastic disease. There are multiple factors that influence the incidence of thrombosis: advanced disease, presence of a central catheter, chemotherapy, type of tumor, surgery, among other. Despite a long-recognized association between cancer and thrombosis, few data are available regarding the incidence of venous thromboembolism among patients with specific types of cancer, such as colorectal cancer. The objective of this review was to describe the incidence, disease course, risk factors, and prognosis associated with venous thromboembolism in patients with colorectal cancer. Activated coagulation and cancer tissue form a mutual positive-feedback loop, and strategies that interfere with this loop may be an interesting new strategy for cancer and thromboembolism prevention or treatment.

Key words: Venous thromboembolism, deep vein thrombosis, pulmonary embolism, colorectal cancer, colorectal surgery, chemotherapy.


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