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2016, Number 3

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Rev Hematol Mex 2016; 17 (3)

Vitamin B12 deficiency as a cause of thrombosis

Salinas-Rojas V, Fernández B, Salinas- Herrera VI

Language: Spanish
References: 19
Page: 220-224
PDF size: 406.13 Kb.


ABSTRACT

Thrombophilia is a coagulation disorder of the blood that predisposes to the development of thrombosis. Predisposing causes are numerous and involve morbid inherited or acquired states. Acquired disorders are more frequent than the inherited and often are these that facilitate the expression of the inherited disorders. The deficiency of vitamin B12 as cause of thrombophilia is not considered a factor to study in patients who develop thrombosis. We present evidence of the relationship between thrombophilia and vitamin B12 deficiency through two cases with thrombosis in unusual sites, in which the only detectable alteration was vitamin B12 deficiency. In those patients that developed vascular thrombotic events, we quantified serum homocysteine, vitamin B12, methylmalonic acid, folates and markers of thrombophilia. In both cases there was deficit of vitamin B12 associated to hyperhomocysteinaemia and elevation of methylmalonic acid. Vitamin B12 replacement therapy was associated with good response. The deficiency of vitamin B12 is cause of thrombophilia. This predisposition is related to the development of hyperhomocysteinaemia, although other concurrent factors can participate in specific cases. Anemia may or not be present, and sometimes can be hidden for other causes of anemia, as in one of the cases presented.


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