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2016, Number 4

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Rev Hematol Mex 2016; 17 (4)

Primary adrenal lymphoma: a report of two cases and review of the disease in Latin America

Jaramillo-Calle DA, Giraldo MB, Quintero-Múnera CD, Mejía-Buriticá L, Pinzón-Tovar A, Cubillos J, Luna R, Rendón-Henao J, Román-González A

Language: Spanish
References: 15
Page: 293-300
PDF size: 565.87 Kb.


ABSTRACT

Primary adrenal lymphoma is a rare disease with around 200 case reports, of which only 4 come from Latin America. In this article, two new cases in the region are reported which were initially considered to be urolithiasis and pheochromocytoma. Our aim is to show the importance of considering this entity in the differential of atypical cases of abdominal pain and diagnostic images of masses in the adrenal area. Besides, review all the Latin-American cases and describe the most common clinical presentations and outcomes. The first case is a 53 years-old man with acute abdominal pain and B-symptoms in who initially urolithiasis was suspected, but whose CT urography demonstrated a left adrenal mass, which was subsequently identified by histology as a diffuse large B-cell lymphoma, against which he was treated with R-CHOP chemotherapy up to achieving complete remission. The second case is a 21 years-old man with a personal history of schizophrenia who presented acute hypogastric pain associated with facial flushing, profuse sweating, palpitations, a mass in the adrenal area, and a slightly increasing of catecholamines, reasons why he was initially diagnosed with pheochromocytoma. However, the histopathologic study identified the mass as a diffuse large B-cell lymphoma without medullary neoplasia, so he was treated with R-CHOP until his death. After analyzing the 6 Latin-American cases together it was found that they frequently presented severe neurological symptoms due to dissemination of the lymphoma to central nervous system and they were diagnosed in advanced stages.


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