2016, Number 07
Association between Subclinical Hypothyroidism and Hypertensive Pregnancy-induced disease
Campos-Hinojosa SE, García-de la Torre JI, Garza-Martínez LE
Full text
Language: Spanish
References: 13
Page: 413-419
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ABSTRACT
Background: Subclinical hypothyroidism is defined as elevated thyroid stimulating hormone in the presence of normal T4 free fraction, its prevalence is estimated at between 2-5% in the pregnant population and took a special interest after several observational studies where he associated to a higher rate of perinatal complications, including the development of hypertensive disease induced by pregnancy, predominantly severe preeclampsia.Objetive: Demonstrating the highest prevalence of subclinical hypothyroidism in those patients with pregnancy-induced group compared to normotensive and hypertensive disease if their carry it predisposes to the severity of the disease.
Material and Methods: A prospective, longitudinal, descriptive, case-control studies of women attended during childbirth at the University Hospital of Saltillo, between June 2012 and January 2015, consisting of measuring serum thyroid stimulating hormone and fraction study free T4. Cases were considered patients diagnosed with hypertensive disease of pregnancy, further divided into two subgroups identified as patients with and without subclinical hypothyroidism. And was called to controls patients without known thyroid dysfunction, further divided into two subgroups identified as: patients with and without subclinical hypothyroidism.
Results: 78 records of only 274 met the inclusion criteria were analyzed. The incidence of subclinical hypothyroidism (42.3%) was significantly higher in hypertensive patients than in normotensive (22.8%), with p = 0.007. No association between subclinical underactive thyroid and increased severity of hypertensive disease or other perinatal complications, longer hospital stay but found.
Conclusions: Early screening of thyroid function will identify those women carrying some dysfunction, particularly subclinical hypothyroidism, as subjects of increased risk for developing hypertensive disease of pregnancy and establish a prevention, vigilance and timely handling.
REFERENCES
Alex Stagnaro-Green (Chair), Marcos Abalovich, Erik Alexander, Fereidoun Azizi, Jorge Mestman, Roberto Negro, Angelita Nixon, Elizabeth N. Pearce, Offie P. Soldin, Scott Sullivan and Wilmar Wiersinga. Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and Postpartum. Thyroid Preg Fetal Develop 2011;21(10).