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Federación Mexicana de Ginecología y Obstetricia, A.C.

2017, Number 11

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Ginecol Obstet Mex 2017; 85 (11)

Optimal number of oocytes: In vitro fertilization predictive model

López-Rioja MJ, Campos-Cañas JA, Recio-López Y, Quiroz-Garza G, Sánchez-González CM, Hinojosa-Rodríguez K, Laresgoiti-Servitje E

Language: Spanish
References: 20
Page: 735-747
PDF size: 467.93 Kb.


ABSTRACT

Objetive: Develop a model to optimize the reproductive outcome (live birth rate). Identify the minimal number of oocytes to capture.
Materials and Methods: Observational, longitudinal, and retrolective study was made. In fresh IVF cycles, performed at INPer between 2011-2016. A logistic regression model was fitted with a CHAID, and performed a decision tree to predict live birth (LBR). Inclusion criteria: patients over 18 years of age, diagnosed with infertility, who underwent in vitro fertilization with fresh embryo transfer (FIV-TE). The study variables were: age, BMI, basal FSH concentration, type of infertility, time of infertility and number of oocytes captured. A decision tree type CHAID and a binary logistic regression model were performed. Statistical Package for Social Sciences (SPSS) was used for the statistical analysis. The probability of error alpha ‹5% was considered significant.
Results: A total of 673 cycles were studied. The optimal number was ›12 oocytes (OR = 4.666, 95% CI: 2.676-8.137, p=‹0.01). The highest chance to have LB (28%), was in women ‹37 years old, with FSH ‹4.2 mIU / mL and ‹5 oocytes; χ2 = 7.797 (df = 1, p = ‹0.047). The lowest chance was in 38-40 years (OR = 0.338, 95% CI: 0.147- 0.776, p = ‹0.011) with a longer lapse of infertility; 10-12 years (OR = 0.394, 95% CI: 0.181-0.858, p = 0.019).
Conclusion: Our data suggest that in the ›12 oocytes may be the optimal number to obtain, independent of the age. On the other hand the best chance to have a live birth is with an age ‹37, FSH ‹4.2 mIU/ mL and ‹5 oocytes. Fewer oocytes than previously deemed optimal, because the probability of having a euploid embryo in this group of people is much bigger.


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