2018, Number 2
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ABSTRACTBackground: The transdermal administration of analgesic is a noninvasive method of drug administration. Although the indication for its use is chronic pain, its use in post-operative acute pain can be a good option reason why the objective of this study was to evaluate the effectiveness of specific doses in abdominal hysterectomy, as well as the potential adverse effects. Material and methods: Controlled Clinical Trial Administer transdermal buprenorphine of 10 mg, 15 mg and 20 mg, compared with placebo. The intensity of the pain to 30 min, 60 min, 90 min, 120 min, 4 hours, 8 hours, 12 hours, 16 hours, 20 hours and 24 hours, in rest and to the movement was evaluated. Statistic analysis: Chi square (χ2) was used for qualitative variables, an analysis of variance (ANOVA) to compare the groups as well as post hoc tests by the Turkey method, statistical significance was considered if p ‹ 0.05. Results: The mean of pain in movement in group 1 was 2.07 ± 1.08 for group 1.5 from 2.0 ± 1 for group 2 of 1.87 ± 1.02, for group P it was 3.3 ± 1.98 The VAS at rest for all groups was 1.0 ± 0; except for the control that was 2.8 ± 1.02. Adverse reactions were in group 1 of 53.6% nausea in 11.25%, drowsiness in 42.35%. Group 1.5 67.73% presented, being only drowsiness the event found. For group 2, 82.79% presented adverse events, of these 5.42% presented nausea and 77.37% somnolence. Conclusion: It is an effective and safe alternative for the management of the post-operative pain.
Cerruela G, Fernandez A, Baez ME. Eficacia del parche transdermico de buprenorfina en el tratamiento del dolor postoperatorio. [Internet] Cartel presentado en VIII congreso centroamericano y del Caribe de anestesiologia y reanimacion 21 al 24 de octubre 2008 La Habana Cuba. Disponible en: http://www.fesacac2008.sld.cu/Members/gcerruela/eficacia-del-parche-transdermico-de-buprenorfina-en-el-tratamiento-del-dolor-postoperatorio/