Curiel LFB, Ruiz MB, Román MSM, Panduro CA

Language: Spanish
References: 18
Page: 79-84
PDF size: 166.30 Kb.

ABSTRACT

Gallstone disease (GSD) affects 14% of Mexican population. Family studies suggest that genetics plays an important role, so that research has been conducted to find the association between specific gene polymorphisms and GSD. In western countries, cholesterol gallstones are more prevalent than pigment stones, and many studies are focused on the research of genes related with cholesterol metabolism and gallstone formation. Several genetic polymorphisms have been identified regarding GSD, such as apo E (E4) and apo B (XbaI). These genes are involved in the binding of LDL, thus enhancing the hepatic and biliary concentration of cholesterol and gallstone formation. Other related genes are: apolipoprotein A-I, cholesteryl ester trasfer protein (CETP), members of LDL receptors, lipoprotein lipase (LPL), cholesterol 7-alpha-hydroxylase (CYP7), scavenger receptor class B type I (SR-BI) and the multidrug resistance gen (MDR3).

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