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Revista Mexicana de Trasplantes

ISSN 2007-6800 (Print)
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2018, Number 2

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Rev Mex Traspl 2018; 7 (2)

Evaluation of allocation criteria for deceased donor kidney transplant in adults for a score system in Mexico

Madrigal-Bustamante JA, Cardoso-Arias R, Juárez-Enríquez D, Cantú-Quintanilla GR
Full text How to cite this article

Language: Spanish
References: 8
Page: 41-46
PDF size: 190.22 Kb.


Key words:

Allocation criteria, kidney transplant, histocompatibility, score system, efficiency, equity.

ABSTRACT

Deceased donor kidney allocation is an essential part of the organ donation and transplant process. Most kidney allocation systems worldwide are based on a score method with specific criteria and rules oriented to justice, equity and efficiency. Mexico doesn’t have this type of allocation system on an institutional, regional or national level. We evaluated allocation criteria used by the main deceased donor kidney transplant centers in the country, availability of histocompatibility tests and their posture on score-based kidney allocation systems, to generate a bioethics and medical discussion about current allocation practices and the subject’s future in Mexico. The criteria used in a consistent way among programs are waiting list time, availability of vascular access (urgency criteria) and adherence to treatment. Most programs don’t consider histocompatibility tests (HLA mismatch, DSA), donor and recipient sex, type of dialysis, ESRD etiology, and economic resources. A future system should consider time spent on dialysis, donor and recipient age, PRA percentage, DSA presence, living donor availability, family support network and presence of comorbidities. Regarding histocompatibility tests, 71% contemplate them as a requisite in their protocols, and 85% have a laboratory available: 57% are institutional and 29% regional or state-based; 83% are public and 17% private. 71% of the programs agree on merging waitlists on a state-based or regional level, and 86% agree on participating in a pilot program. The goal of this study is to support the planning and design of a new score-based kidney allocation system that allows a more efficient and transparent decision, to obtain better results and a fair distribution of a scarce resource such as deceased donor kidneys.


REFERENCES

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  2. Centro Nacional de Trasplantes. Informe Anual 2017 sobre donación y trasplante. 2017. Disponible en: https://www.gob.mx/cenatra/documentos/estadisticas-50060

  3. Pippias M, Stel VS, Abad Diez JM, Afentakis N, Herrero-Calvo JA, Arias M et al. Renal replacement therapy in Europe: a summary of the 2012 ERA-EDTA Registry Annual Report. Clin Kidney J. 2015; 8 (3): 248-261.

  4. De Ortúzar MG. Ethics and quality of life of kidney transplant patient. Transplant Proc. 2001; 33 (1-2): 1913-1916.

  5. Mayer G, Persijn GG. Eurotransplant kidney allocation system (ETKAS): rationale and implementation. Nephrol Dial Transplant. 2006; 21 (1): 2-3.

  6. Domínguez CJ. Sistema de distribución de órganos en Chile: propuestas para una modificación de la distribución de riñones de donantes cadavéricos para trasplante. Rev Med Clin Condes. 2010; 21 (2): 179-185.

  7. Takemoto SK, Terasaki PI, Gjertson DW, Cecka JM. Twelve years’ experience with national sharing of HLA-matched cadaveric kidneys for transplantation. N Engl J Med. 2000; 343 (15): 1078-1084.

  8. Orandi BJ, Luo X, Massie AB, Garonzik-Wang JM, Lonze BE, Ahmed R et al. Survival benefit with kidney transplants from HLA-incompatible live donors. N Engl J Med. 2016; 374 (10): 940-950.




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Rev Mex Traspl. 2018;7