2018, Number 1
Autoimmune hemolytic anemia from Donath-Landsteiner biphasic hemolysin. A case report
Navarrete-Castro J, Siria-Torreblanca N, González-Avante M, Navarrete-Castro R
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Language: Spanish
References: 7
Page: 22-25
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ABSTRACT
Background: Among the autoimmune hemolytic anemias (AIHA), one of the most clinically relevant is undoubtedly autoimmune hemolytic anemia due to biphasic hemolysin from Donath-Landsteiner (paroxysmal to frigore hemoglobinuria (PFH)) due to its high incidence in children, since which represents between 30 and 40% of the total child AHAI. That justifies the relevance of the case. Material and methods: The study protocol for hemolytic anemia (HA) established in our institution was carried out, which implies: group and Rh, Rh phenotype, direct Coombs (DC) polyspecific and monospecific, indirect Coombs (IC), Eluate, Donath-Landsteiner test and erythrocytic phenotype for Ag P. Results: The patient had a positive «O» blood group, Rh phenotype: R1R1, polyspecific DC: positive (titre 1:4), monospecific DC: positive to C3d, eluded: negative, IC: negative, IC from eluate: positive with anti-P specificity, Donath-Landsteiner test: positive, erythrocytic phenotype for Ag P: positive. Conclusions: The presence of PFH is a rare entity in the total population, which according to the world literature, is present in a prevalence of 2 to 5% of the total AIHA. We report case number 1 of two cases currently detected from 2010 to date.REFERENCES