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2018, Number 1

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Rev Med MD 2018; 9.10 (1)

Mean platelet volume as diagnostic marker of acute appendicitis

Evaristo-Méndez G, Hermosillo-Pérez SN

Language: Spanish
References: 35
Page: 11-17
PDF size: 568.17 Kb.


ABSTRACT

Introduction. Mean platelet volume (MPV) has been proposed as a diagnostic, prognostic and response biomarker for treatment in various inflammatory diseases, including acute appendicitis (AA), but its results are variable and confusing. This work was conducted to evaluate whether MPV can be used as a diagnostic marker in patients with and without AA, as well as between patients with uncomplicated AA (AAnC) and complicated AA (AAC).
Material and Methods. In a case-control study, men and women › 18 years of age were included. Patients with acute intra-operative pathology different from AA and if post-operative histopathology did not demonstrate its presence were excluded from the final analysis. The group with AA was formed of 107 patients and the group without AA with 217 patients. The cases of AA were categorized as UAA (n = 75) and CAA (n = 32). In all groups the MPV, platelet count, leukocytes and neutrophils were determined.
Results. There was no statistically significant difference in MPV (p = 0.249) between patients with AA and without AA. The MPV was higher in the group with CAA than in the group with UAA (p = 0.038). In the analysis of the receiver operating characteristic curve, the area under the curve for the MPV and the presence of CAA was 0.66 (p = 0.007, 95% CI: 0.55 - 0.77). The MPV cut-point ≥ 10.8 fL in predicting CAA combined a sensitivity of 68.8% with a specificity of 57.3%, a positive predictive value of 22.81% and a negative predictive value of 62%; the positive likelihood ratio was 0.69 and the negative likelihood ratio was 1.44.
Discussion. The MPV has no clinical utility as a diagnostic marker in cases of UAA and CAA.


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