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Organo Oficial de la Sociedad Mexicana de Urología

2018, Number 6

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Rev Mex Urol 2018; 78 (6)

Study on vitamin D receptor gene polymorphisms in patients with urinary tract infections conducted in Northwestern Mexico

Becerra-Loaiza DS, Sánchez-Zazueta JG, Ochoa-Ramírez LA, Velarde-Rodríguez I, Rodríguez-Millán J, Velarde-Félix JS

Language: English
References: 27
Page: 419-424
PDF size: 288.27 Kb.


ABSTRACT

Objective: To evaluate the influence of the polymorphisms of the vitamin D receptor gene (FokI: rs2228570, BsmI: rs1544410, ApaI: rs7975232, and TaqI: rs731236) on the clinical parameters of patients with urinary tract infections.
Materials and Methods: A comparative, prospective, and cross-sectional study was conducted at the Hospital General de Culiacán Dr. Bernardo J. Gastélum within the time frame of August 2016 to July 2017. The polymorphisms were detected through the polymerase chain reaction-restriction fragment length method in 119 patients diagnosed with urinary tract infection and in 206 individuals with no urinary tract infection. The data analysis was carried out using the χ2 and odds ratio (OR) with a 95% confidence interval (95%CI). The logistic regression method, adjusted by age and sex, was employed to evaluate the relation between clinical characteristics and genotypes, utilizing the STATA version 13.0 program. Statistical significance was set at a p‹0.05.
Results: We found differences in the prevalence of the CA-ApaI genotype between the study groups. The FokI and BsmI polymorphisms and the TGAT and CGCT haplotypes were associated with certain clinical characteristics.
Conclusions: A possible link between the vitamin D receptor gene and bacterial urinary tract infection in a Mexican population was suggested.


REFERENCES

  1. Flores-Mireles AL, et al. Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiol 2015;13(5):269-84. DOI: 10.1038/nrmicro3432

  2. Godaly G, Ambite I, Puthia M, et al. Urinary tract infection molecular mechanisms and clinical translation. Pathogens 2016;5(1):E24. DOI: 10.3390/pathogens5010024

  3. Ragnarsdóttir B, et al. Genetics of innate immunity and UTI susceptibility. Nat Rev Urol 2011;8(8):449-68. DOI: 10.1038/ nrurol.2011.100

  4. Hertting O, et al. Vitamin D induction of the human antimicrobial peptide cathelicidin in the urinary bladder. PLoS One 2010;5:e15580. DOI: 10.1371/journal.pone.0015580

  5. Tekin M, et al. The association between vitamin D levels and urinary tract infection in children. Horm Res Paediatr 2015;83(3):198-203. DOI: 10.1159/000370046

  6. Nseir W, et al. The association between serum levels of vitamin D and recurrent urinary tract infections in premenopausal women. Int J Infect Dis 2013;17(12):e1121-4. DOI: 10.1016/j.ijid.2013.06.007

  7. Övünç-Hacıhamdioğlu D, et al. The association between serum 25-Hydroxy Vitamin D level and urine cathelicidin in children with a urinary tract infection. J Clin Res Pediatr Endocrinol 2016;8(3):325-9. DOI: 10.4274/jcrpe.2563

  8. Aslan S, et al. Vitamin D receptor gene polymorphism in children with urinary tract infection. Pediatr Nephrol 2012;27(3):417-21. DOI: 10.1007/s00467-011-2000-0

  9. Kinnear C, et al. The role of human host genetics in tuberculosis resistance. Expert Rev Respir Med 2017;11(9):721-37. DOI: 10.1080/17476348.2017.1354700

  10. Velarde-Félix JS, et al. Association between the TaqI polymorphism of the vitamin D receptor gene and lepromatous leprosy in a Mexican population sample. Salud Publ Mex 2009;51(1):59-61. Dirección URL: < https:// scielosp.org/scielo.php?script=sci_arttext&pid=S0036- 36342009000100011&lng=en&nrm=iso&tlng=en>.

  11. Han WG, Hodemaekers HM, Nagarajah B, et al. Association of Vitamin D Receptor polymorphism with susceptibility to symptomatic pertussis. PLoS One 2016(2);11:e0149576. DOI: 10.1371/journal.pone.0149576

  12. EAU (European Association of Urology). Guidelines on Urological Infections. European Association of Urology, 2015. Available at https://uroweb.org/wp-content/uploads/19- Urological-infections_LR2.pdf. Accessed January 2018.

  13. Gustincich S, et al. A fast method for high-quality genomic DNA extraction from whole human blood. Biotechniques 1991;11(3):298-300,302.

  14. Shafia S, et al. Role of vitamin D receptor (VDR) polymorphisms in susceptibility to multiple myeloma in ethnic Kashmiri population. Blood Cells Mol Dis 2013;51(1):56-60. DOI: 10.1016/j.bcmd.2013.02.001

  15. Li K, et al. The association of vitamin D receptor gene polymorphisms and serum 25-hydroxyvitamin D levels with generalized vitiligo. Br J Dermatol 2012;167(4):815-21. DOI: 10.1111/j.1365-2133.2012.11132.x

  16. Shi YY, He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotypes construction, and genetic association at polymorphism loci. Cell Res 2005;15(2):97-8. DOI: 10.1038/sj.cr.7290272

  17. Uitterlinden AG, et al. Genetics and biology of vitamin D receptor polymorphisms. Gene 2004;338(2):143-56. DOI: 10.1016/j.gene.2004.05.014

  18. García Nieto V, et al. Vitamin D receptor polymorphisms and susceptibility to developing urinary tract infection in children diagnosed with idiopathic hypercalciuria. Nefrologia 2002;22(4):390-1.

  19. Zeljic K, et al. Vitamin D receptor gene polymorphisms association with the risk of sepsis and mortality. Int J Immunogenet 2017;44(3):129-34. DOI: 10.1111/iji.12318

  20. Spencer JD, et al. The innate immune response during urinary tract infection in pyelonephritis. Pediatr Nephrol 2014;29(7):1139-49. DOI: 10.1007/s00467-013-2513-9

  21. Gurocak S, et al. The impact of gene polymorphisms on the success of anticholinergic treatment in children with overactive bladder. Dis Markers 2015;2015:732686. DOI: 10.1155/2015/732686

  22. Cartwright R, et al. Systematic review and meta-analysis of candidate gene association studies of lower urinary tract symptoms in men. Eur Urol 2014;66(4):752-68. DOI: 10.1016/j.eururo.2014.01.007

  23. Hicks GE, et al. Associations between vitamin D status and pain in older adults: the Invecchiare in Chianti study. J Am Geriatr Soc 2008;56(5):785-91. DOI: 10.1111/j.1532- 5415.2008.01644.x

  24. Karras S, et al. Vitamin D in fibromyalgia: A causative or confounding biological interplay? Nutrients 2016;4(6):E343. DOI: 10.3390/nu8060343

  25. Cauci S, et al. Low back pain and FokI (rs2228570) polymorphism of vitamin D receptor in athletes. BMC Sports Sci Med Rehabil 2017;9:4. DOI: 10.1186/s13102-017-0069-x

  26. Muraki S, et al. Association of vitamin D status with knee pain and radiographic knee osteoarthritis. Osteoarthritis Cartilage 2011;19(11):1301-06. DOI: 10.1016/j. joca.2011.07.017

  27. Helde-Frankling M, Björkhem-Bergman L. Int J Mol Sci 2017;18(10):E2170. DOI: 10.3390/ijms18102170




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