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2019, Number 4

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Rev Hematol Mex 2019; 20 (4)

Paraneoplastic nephrotic syndrome, an infrequent manifestation in acute lymphoblastic leukemia in children

Liquidano-Pérez E, González-Pedroza ML, López-Santiago NC, Londoño-Urrea V, Paredes-Aguilera RA

Language: Spanish
References: 10
Page: 283-286
PDF size: 244.70 Kb.


ABSTRACT

Nephrotic syndrome as a paraneoplastic manifestation of acute lymphoblastic leukemia is infrequent in the pediatric age. This paper reports the case of a 2-year-old male with a 3-day history of pallor, asthenia, adynamia and palpebral edema. At physical examination the patient presented 5 mm mobile, non-painful, neck adenomegalies, hepatomegaly, palpebral and lower limb edema; therefore, we suspected nephrotic syndrome. With laboratory studies and bone marrow aspiration showing 100% blasts, a diagnosis of acute lymphoblastic leukemia was established. Given the lack of information about NS as an initial manifestation of acute lymphoblastic leukemia in pediatrics, the exact mechanism for nephrotic syndrome development has not been established. Due to the rare presentation of paraneoplastic nephrotic syndrome in acute lymphoblastic leukemia, it will always be necessary the intentional search of the nephrotic syndrome’s cause, which will improve diagnostic accuracy and specific treatment that changes the patients’ survival.


REFERENCES

  1. Román Ortiz E. Síndrome nefrótico pediátrico. Protoc Diagn Ter Pediatr 2014;1:283-301.

  2. Luciano RL, Brewster UC. Kidney involvement in leukemia and lymphoma. Adv Chronic Kidney Dis 2014;21(1):27-35. Doi: 10.1053/j.ackd.2013.07.004.

  3. Arenas MD, Gil MT, Malek T, Farré J, Fernández Morejón FJ, Arriero JM, et al. Nephrotic syndrome as paraneoplastic manifestation of a primary pulmonary lymphoepitheliomalike carcinoma. Clin Nephrol 2009;72(3):206-210. DOI: 10.5414/cnp72206.

  4. Springate JE, Brecher M, Brentjens J, Feld LG. Glomerulonephritis and chronic myelogenous leukemia. Child Nephrol Urol 1988-1989;9(5):298-300.

  5. Le Berre L, Bruneau S, Naulet J, Renaudin K, Buzelin F, Usal C, et al. Induction of T regulatory cells attenuates idiopathic nephrotic syndrome. J Am Soc Nephrol 2009;20(1):57-67. Doi: 10.1681/ASN.2007111244.

  6. Sudholt BA, Heironimus JD. Chronic myelogenous leukemia with nephrotic syndrome. Arch Intern Med 1983;143(1):168-169.

  7. Sahiner S, Ayli MD, Yuksel C, Onec K, Abayli E. Membranous nephropathy associated with acute myeloid leukemia. Transplant Proc 2004;36(9):2618-2619. DOI: 10.1016/j. transproceed.2004.09.082.

  8. Gagliano RG, Costanzi JJ, Beathard GA, Sarles HE, Bell JD. The nephrotic syndrome associated with neoplasia: an unusual paraneoplastic syndrome. Report of a case and review of the literature. Am J Med 1976;60(7):1026-31. DOI: 10.1016/0002-9343(76)90575-1.

  9. Khositseth S, Kanitsap N, Warnnissorn N, Thongboonkerd V. IgA nephropathy associated with Hodgkin’s disease in children: a case report, literature review and urinary proteome analysis. Pediatr Nephrol 2007;22(4):541-6. DOI: 10.1007/s00467-006-0382-1

  10. Kasprzak A, Olejniczak K, Przybyszewska W, Zabel M. Cellular expression of interleukin 2 (IL-2) and its receptor (IL-2R, CD25) in lung tumours. Folia Morphol (Warsz). 2007;66(3):159-66.




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