medigraphic.com
SPANISH

Revista Mexicana de Patología Clínica y Medicina de Laboratorio

ISSN 0185-6014 (Print)
Órgano oficial de difusión de la Federación Mexicana de Patología Clínica, AC y de la Asociación Latinoamericana de Patología Clínica/Medicina de Laboratorio
  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Instructions for authors        
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2020, Number 1

Next >>

Rev Mex Patol Clin Med Lab 2020; 67 (1)

How to estimate the lethality of COVID-19

Simón DJI, Simón DN, Reyes NMA
Full text How to cite this article 10.35366/93845

DOI

DOI: 10.35366/93845
URL: https://dx.doi.org/10.35366/93845

Language: Spanish
References: 35
Page: 4-8
PDF size: 217.37 Kb.


Key words:

Pandemic, COVID-19, lethality.

ABSTRACT

The purpose of this document is to present a simple and empirical model to estimate the fatality of COVID-19 and to answer the question: ¿What is the number of people infected with SARS-CoV-2 in each country? Material and methods: A review of the previous studies was carried out, of the risk factors that influence a higher mortality, the number of deaths, and it was concluded to select a lethality parameter for the simulations with the proposed model, using the database of the European Center for Disease Prevention and Control, accessible on the platform: https://ourworldindata.org/coronavirus, as of 1/4/2020 and with daily updates. Results: Lethality was adjusted to 0.9524%, the mean being 1.02%, with a range of 0.65-1.34% (149 countries). To validate our model, the figures obtained with the simulation were compared with those reported by Russia (the country with the most tests per inhabitants 6.45%), with the following results for the day 2/5/2020: for confirmed cases, our estimate had a difference of -0.44%; for lethality of +0.01% and for prevalence of 0.00%. Conclusions: Our model is useful for estimating case fatality, prevalence and its variations from one country to another, which is essential to support governments in choosing appropriate strategies and avoid population uncertainty.


REFERENCES

  1. Wu P, Hao X, Lau EHY et al. Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020. Euro Surveill. 2020; 25 (3): 2000044. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988272/

  2. Chan KW, Wong VT, Tang SCW. COVID-19: an update on the epidemiological, clinical, preventive and therapeutic evidence and guidelines of integrative Chinese-western medicine for the management of 2019 Novel Coronavirus Disease. Am J Chin Med. 2020; 48 (3): 737-762. Available in: https://www.ncbi.nlm.nih.gov/pubmed/32164424

  3. WHO Director-General’s opening remarks at the media briefing on COVID-19 [11 March 2020]. Available in: https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020

  4. Roser M, Ritchie H, Ortiz-Ospina E, Hasell J. Coronavirus Pandemic (COVID-19). Published online at OurWorldInData.org. 2020. Retrieved from: https://ourworldindata.org/coronavirus

  5. Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 2020; 109: 102433. Available in: https://doi.org/10.1016/j.jaut.2020.102433

  6. Wayne Dimech B. Part 1: key facts in COVID-19 test. WESTGARD WEB April 2020.

  7. Lippi G, Plebani M. Laboratory abnormalities in patients with COVID-2019 infection [published online ahead of print, 2020 Mar 3]. Clin Chem Lab Med. 2020. Available in: https://doi.org/10.1515/cclm-2020-0198

  8. Gautret P, Lagier JC, Parola P et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial [published online ahead of print, 2020 Mar 20]. Int J Antimicrob Agents. 2020; 105949. Available in: https://doi.org/10.1016/j.ijantimicag.2020.105949

  9. Devaux CA, Rolain JM, Colson P, Raoult D. New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? Int J Antimicrob Agents. 2020; 55 (5): 105938. Available in: https://doi.org/10.1016/j.ijantimicag.2020.105938

  10. Ko WC, Rolain JM, Lee NY et al. Arguments in favour of remdesivir for treating SARS-CoV-2 infections. Int J Antimicrob Agents. 2020; 55 (4): 105933. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135364/

  11. Huang C, Wang Y, Li X et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395: 497-506.

  12. Chen N, Zhou M, Dong X et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020; 395: 507-513.

  13. Wang D, Hu B, Hu C et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China [published online ahead of print, 2020 Feb 7]. JAMA. 2020; 323 (11): 1061-1069. doi: 10.1001/jama.2020.1585.

  14. WHO. WHO Director-General’s opening remarks at the media briefing on COVID-19. March 3, 2020. Available in: https://www.who.int/dg/speeches/detail/who-director-general-sopening-remarks-at-the-media-briefing-oncovid-19---3-march-2020

  15. Johns Hopkins Center for Systems Science and Engineering. Coronavirus COVID-19 global cases. 2020. Available in: https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6

  16. CNA. Diamond Princess passenger dies, bringing ship’s death toll to seven. March 8, 2020. Available in: https://www.channelnewsasia.com/news/asia/coronavirus-covid19-japandiamond-princess-deaths-12513028

  17. Pappas S. How deadly is the new coronavirus? March, 2020. Available in: https://www.livescience.com/iscoronavirus-deadly.html

  18. Munster VJ, Koopmans M, van Doremalen N, van Riel D, de Wit E. A novel coronavirus emerging in China-key questions for impact assessment. N Engl J Med. 2020; 382: 692-694.

  19. de Wit E, van Doremalen N, Falzarano D, Munster VJ. SARS and MERS: recent insights into emerging coronaviruses. Nat Rev Microbiol. 2016; 14: 523-534.

  20. Fauci AS, Lane HC, Redfield RR. Covid-19 - Navigating the uncharted. N Engl J Med. 2020; 382 (13): 1268-1269. doi: 10.1056/NEJMe2002387.

  21. Rajgor DD, Lee MH, Archuleta S, Bagdasarian N, Quek SC. The many estimates of the COVID-19 case fatality rate [published online ahead of print, 2020 Mar 27]. Lancet Infect Dis. 2020. doi: 10.1016/S1473-3099(20)30244-9.

  22. Miletto Granozio F. On the problem of comparing COVID-19 fatality rates. Available in: https://arxiv.org/ftp/arxiv/papers/2004/2004.03377.pdf

  23. McFall-Johnsen JK, Lauren Frias M. A third of the global population is on coronavirus lockdown here’s our constantly updated list of countries and restrictions. Business Insider. Available in: https://www.businessinsider.com/countries-on-lockdown-coronavirus-italy-2020-3. Accessed April 6, 2020.

  24. Baud D, Qi X, Nielsen-Saines K, Musso D, Pomar L, Favre G. Real estimates of mortality following COVID-19 infection [published online ahead of print, 2020 Mar 12]. Lancet Infect Dis. 2020; S1473-3099(20)30195-X. doi: 10.1016/S1473-3099(20)30195-X.

  25. Spychalski P, Błayska-Spychalska A, Kobiela J. Estimating case fatality rates of COVID-19 [published online ahead of print, 2020 Mar 31]. Lancet Infect Dis. 2020; S1473-3099(20)30246-2. doi: 10.1016/S1473-3099(20)30246-2.

  26. Elisabeth M. Coronavirus: covid-19 has killed more people than SARS and MERS combined, despite lower case fatality rate. BMJ. 2020; 368: m641. https://doi.org/10.1136/bmj.m641.

  27. Villa M. COVID-19 and Italy’s case fatality rate: ¿what’s the catch? Available in: https://www.ispionline.it/sites/default/files/pubblicazioni/ispi_analysis_italy_covid19_lethality_villa_mar2020.pdf

  28. Rinaldi G, Paradisi M. An empirical estimate of the infection fatality rate of COVID-19 from the first Italian outbreak. medRxiv. 2020. Available in: https://doi.org/10.1101/2020.04.18.20070912

  29. De Natale G, Ricciardi V, De Luca G et al. The COVID-19 infection in Italy: a statistical study of an abnormally severe disease. J Clin Med. 2020; 9 (5): E1564. doi: 10.3390/jcm9051564.

  30. Oke J, Heneghan C. Global COVID-19 case fatality rates. Oxford, UK: Nuffield Department of Primary Care Health Sciences; 2020. Available online: https://www.cebm.net/global-COVID-19-case-fatality-rates/

  31. Lauer SA, Grantz KH, Bi Q et al. The incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: estimation and application. Ann Intern Med. 2020; 172 (9): 577-582. doi: 10.7326/M20-0504.

  32. Tátrai D, Várallyay Z. COVID-19 epidemic outcome predictions based on logistic fitting and estimation of its reliability. arXiv:2003.14160.

  33. Baumgaertner E. How deadly is the new coronavirus? Scientists race to find the answer. Feb 12, 2020. [accessed March 19, 2020] Available in: https://www.latimes.com/ science/story/2020-02-11/how-deadly-iscoronavirus-fatality-rate

  34. Wighton K, van Elsland S L. Coronavirus fatality rate estimated by Imperial scientists. Feb 11, 2020. [accessed March 19, 2020] Available in: https://www.imperial.ac.uk/news/195217/coronavirus-fatality-rateestimated-imperial-scientists

  35. WHO. Diabetes country profiles. 2016. Available in: https://www.who.int/diabetes/country-profiles/en/




2020     |     www.medigraphic.com

Mi perfil

C?MO CITAR (Vancouver)

Rev Mex Patol Clin Med Lab. 2020;67