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Colegio de Medicina Interna de México.

2020, Number 4

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Med Int Mex 2020; 36 (4)

Immunity, inflammation and thrombosis. Trying to understand the infection due to COVID-19

Rodríguez-Weber FL, Rodríguez-Armida M, Nava-Santana CA

Language: Spanish
References: 20
Page: 557-561
PDF size: 216.71 Kb.


ABSTRACT

The disease caused by SARS-CoV-2 was first reported on December 2019 and ultimately declared as a pandemic in March 2020. Since then, there has been a lot of information released about the possible mechanisms associated with disease in COVID-19. Several components have been proposed, such as direct viral cytophatic injury, disregulated activation of the immune system and coagulation pathways. These events ultimately lead to multiple organ failure and disseminated intravascular coagulation. Based on reports of large series of patients with the disease it has been shown that certain biomarkers (e.g. ferritin, D-dimer, IL-6, etc.) correlate with disease severity and outcomes. A review of the main biomarkers and their pathophysiology are reviewed in this article.


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