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>Journals >Gaceta Médica de México >Year 2013, Issue 5

Cid CDM, Ruiz PMD, Sánchez SLM, Staines BAT, Castro PJ, Palacios SGC
Clinical and immunological characteristics in pediatric patients with coccidioidomycosis in northeastern Mexico
Gac Med Mex 2013; 149 (5)

Language: Español
References: 19
Page: 541-547
PDF: 88.76 Kb.

Full text


Background: Coccidioidomycosis is a systemic fungal disease caused by Coccidioides spp. Patients with phagocytic, cellular, or humoral immunodeficiencies exhibit immunodeficiencies that confer increased susceptibility to fungal infections. In Mexico there is an underreporting of this disease and no studies currently describe the immune status of these patients in an endemic area. Objective: To describe the clinical and immunological characteristics of pediatric patients with coccidioidomycosis. Materials and methods: Pediatric patients with diagnosis of coccidioidomycosis from two tertiary level hospitals of northeastern Mexico were included, from the period 2008-2012; immune status was assessed by clinical history, immunoglobulins levels, levels of lymphocytes T, B, and NK (natural killer), and the nitroblue tetrazolium test. Results: Thirty patients were included, 18 male (60%). The age at diagnosis was five years (median, range 0.25-13). Twelve were from Coahuila (40%). Residual pulmonary coccidioidomycosis was the clinical type presentation found in 16 patients (53%). A primary humoral immunodeficiency was found in three patients (10%) and a secondary immunodeficiency in another three (10%). Case fatality rate was 16%. Conclusions: The disease predominated in male patients. In 33% of patients, levels of IgG were elevated, probably due to stimulation by chronic fungal infection. In 20% of patients, immunodeficiency was documented. There was a high mortality rate.

Key words: Coccidioides immitis, Coccidioidomycosis, Immunodeficiency.


  1. Blair JE, Logan JL. Coccidioidomycosis in solid organ transplantation. Clin Infect Dis. 2001;33(9):1536-44.

  2. Kellner EM, Orsborn KI, Siegel EM, Mandel MA, Orbach MJ, Galgiani JN. Coccidioides posadasii contains a single 1,3-beta-glucan synthase gene that appears to be essential for growth. Eukaryot Cell. 2005;4(1): 111-20.

  3. Ivey FD, Magee DM, Woitaske MD, Johnston SA, Cox RA. Identification of a protective antigen of Coccidioides immitis by expression library immunization. Vaccine. 2003;21(27-30):4359-67.

  4. Antachopoulos C. Invasive fungal infections in congenital immunodeficiencies. Clin Microbiol Infect. 2010;16:1335-42.

  5. Vinh DC, Masannat F, Dzioba RB, Galgiani JN, Holland SM. Refractory disseminated coccidioidomycosis and mycobacteriosis in interferongamma receptor 1 deficiency. Clin Infect Dis. 2009;49(6):62-5.

  6. Vinh DC, Schwartz B, Hsu AP, et al. Interleukin-12 receptor beta1 deficiency predisposing to disseminated Coccidioidomycosis. Clin Infect Dis. 2011;52(4):99-102.

  7. Cox RA, Magee DM. Coccidioidomycosis: host response and vaccine development. Clin Microbiol Rev. 2004;17(4):804-39.

  8. Phillips P, Ford B. Peritoneal coccidioidomycosis: case report and review. Clin Infect Dis. 2000;30(6):971-6.

  9. Bonifaz A. Coccidioidomicosis. Micología Médica Básica. 2.a ed. México, D.F.: Editores M; 1996. p. 235-56.

  10. Cano MA. Coccidioidomicosis pulmonar: 24 años de experiencia en el Hospital Infantil del Estado de Sonora. Rev Mex Ped. 2008;75(4):162-7.

  11. Rosenstein NE, Emery KW, Werner SB, et al. Risk factors for severe pulmonary and disseminated coccidioidomycosis: Kern County, California, 1995-1996. Clin Infect Dis. 2001;32(5):708-15.

  12. Moroyoqui LA. Coccidioidomicosis. Med Int Mex. 2008;24(2):125-41.

  13. Rodney D, Sean P, Mihra S. The Spectrum and Presentation of Disseminated Coccidioidomycosis. Am J Med. 2009;122 (8):770-7.

  14. Ampel NM, Hector RF, Lindan CP, Rutherford GW. An archived lot of coccidioidin induces specific coccidioidal delayed-type hypersensitivity and correlates with in vitro assays of coccidioidal cellular immune response. Mycopathologia. 2006;161(2):67-72.

  15. Holland S. Chronic Granulomatous Disease. Clinic Rev Allerg Immunol. 2010;38:3-10.

  16. Antachopoulos C. Fungal infections in primary immunodeficiencies. Eur J Pediatr. 2007;166:1099-117.

  17. Blair JE. Coccidioidomycosis in Patients With Hematologic Malignancies. Arch Intern Med. 2005;165:113-7.

  18. Laniado R. Coccidioidomicosis. Más que una enfermedad regional. Rev Inst Nal Enf Resp Mex. 2006;19(4):301-8.

  19. Calderón AL. Características clinicopatológicas y distribución del número de autopsias de pacientes fallecidos por coccidioidomicosis en un hospital de referencia del noreste de México. Gac Med Mex. 2004; 140(4):399-404.

>Journals >Gaceta Médica de México >Year 2013, Issue 5

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