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>Journals >Revista de Hematología >Year 2013, Issue 1

Velázquez-Sánchez-de-Cima S, Zamora-Ortiz G, Ruiz-Delgado GJ, Ruiz-Argüelles GJ
Breaking another dogma: Successful hematopoietic stem cell transplantation in patients over 60 years of age: A single institution’s, 20-year experience
Rev Hematol Mex 2013; 14 (1)

Language: Inglés
References: 18
Page: 3-8
PDF: 694.20 Kb.

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Being hematopoietic stem cell transplantation a procedure with a higher risk of morbidity and mortality in older patients, many institutions place a limit of 50 to 55 years for HSCT. With better supportive care the ability to perform transplants successfully in older patients has steadily improved; however, age continues to have a significant impact. In a single institution along a 20-year period, 284 patients were grafted (130 autografts and 154 allografts. In autografted patients above (n = 30) or below (n = 100) 60 years of age, the overall survival (OS) was 67% at 180 months and 58% at 229 months respectively, whereas the median OS has not been reached in any groups, being above 180 and 229 months respectively (p NS), whereas in allografts, in patients above (n = 8) or below (n = 146) 60 years of age, the OS was 50% at 138 months and 38% at 155 months respectively, whereas the median OS was 60 and 20 months respectively (p NS). We conclude that grafting 38 individuals aged 60 years or more (30 autografts and 8 allografts), we have found that the long term-results are similar to those obtained in individuals younger than 60 years.

Key words: BMT, allograft, autograft, age.


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>Journals >Revista de Hematología >Year 2013, Issue 1

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