>Revista de Hematología
>Year 2013, Issue 1
Ramírez-Duarte S, Santoyo-Sánchez A, Collazo-Jaloma J, Salinas-Meritú I, Díaz-Estrada I, Martínez-Murillo C, Ramos-Peñafiel C
Correlation between age and white blood cell count at diagnosis in patients with acute leukemia
Rev Hematol Mex 2013; 14 (1)
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Background: Acute leukemia is the most common cause of cancerrelated death Many variables impact on the prognosis, but age and white blood count are the most important.
Material and methods: Cross-sectional study conducted in patients with diagnosis of acute leukemia in the Hospital General de México and the Hospital General de Cuautitlan between 2006 -2012. Statistical Analysis. Pearson correlation test and lineal regression between age and White blood count at the diagnosis. T- test for the mean difference between White blood count of acute lymphoid and acute myeloid leukemia.
Results: 441 were studied, mostly acute lymphoblastic leukemia (N=279,63.3%) followed by acute myelomonoblastic leukemia (n=65,14.7%) and acute myeloid leukemia with maturation. (n=44, 10%). The median white blood cell count at the diagnosis was 44 x 103/mcL (3.1- 682 x 103/mcL). There were differences between the median white blood cell count at the diagnosis between both leukemias (105.08 x 103/mcL versus 72.51 x 103/mcL, p=0.009, 95% IC (range 8.26- 56.88)]. There was no significant difference in the Pearson correlation test ((p=0.925,95%IC). The R square of the linear regression was 0.005 and 0.000 for acute lymphoblastic leukemia and acute myeloblastic leukemia respectively, with no specific relationship.
Conclusion: Age and White blood count are uncorrelated independent variables. The distribution of the different types of leukemia according to age is the same as other series, hyperleukocytosis is the most common manifestation of acute leukemia.
||Leukemia, age, white blood cell count.
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>Revista de Hematología
>Year 2013, Issue 1