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>Journals >Revista Médica del Instituto Mexicano del Seguro Social >Year 2016, Issue S3


Mata-Hernández A, Rivera-Villa AH, Miguel-Pérez A, Pérez-Atanasio JM, Torres-González R
Sensitivity and antibiotic resistance in infections of the musculoskeletal system
Rev Med Inst Mex Seguro Soc 2016; 54 (S3)

Language: Español
References: 27
Page: 320-324
PDF: 305.58 Kb.


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ABSTRACT

Background: Infections of the musculoskeletal system are a devastating complication for patients, due to it’s long rehabilitation process and even sometimes the removal of the implant, the chronicity of infection, is often due to lack of coverage in empirical antibiotics.
Methods: A retrospective, observational, descriptive cohort study was performed. All cultures form musculoskeletal system infected patients reported of sensitivity and resistance of germs isolated were analyzed.
Results: A total of 143 positive results were included. Reported more frequent germ Staphylococcus aureus accounted for 75 positive cases, followed by Escherichia coli with 31 positive results. Antibiotics with better sensitivity according to the type of microorganisms were trimethoprim- sulfamethoxazole and vancomycin, levofloxacin and linezolid, gentamicin, erythromycin and amikacin. Regarding antibiotic resistance, those reported with the highest percentage were penicillin G, amoxicillin with clavulanic acid and ampicillin.
Conclusions: We recommend using empirical treatments in musculoskeletal system infections, trimethoprim-sulfamethoxazole are the best choice because they have the same sensitivity compare with vancomycin and a resistance rate of 7.6%. Betalactamics have a high percentage of resistance and low sensitivity so we must consider alternatives.


Key words: Drug Resistance, Anti-bacterial agents, Infection, Bone and bones.


REFERENCIAS

  1. Parvizi J, Zmistowski B, Berbari EF, Bauer TW, Springer BD, Della Valle CJ, et al. New definition for periprosthetic joint infection: From the Workgroup of the Musculoskeletal Infection Society. Clin Orthop Relat Res. 2011;469(11):2992-4.

  2. Schinsky MF, Della Valle CJ, Sporer SM, Paprosky WG. Perioperative testing for joint infection in patients undergoing revision total hip arthroplasty. J Bone Joint Surg Am. 2008;90(9):1869-75.

  3. Urish KL, Bs PWD, Kwan BW, Craft DW, Ma D, Haider H, et al. Antibiotic-tolerant Staphylococcus aureus Biofilm Persists on Arthroplasty Materials. Clin Orthop Relat Res. 2016;474(7):1649-56.

  4. Ramírez-Pérez SE, Aurelio MC, Serrano T, Saúl MC, León R. Perfil sociomédico y epidemiológico del paciente con infección ósea. Informe de 202 casos. Revista Mexicana de Traumatología y Ortopedia. 2002; 16(3):154-160.

  5. Ghanem E, Ketonis C, Restrepo C, Joshi A, Barrack R, Parvizi J. Periprosthetic infection: where do we stand with regard to Gram stain? Acta Orthop. 2009; 80(1):37-40.

  6. Bradbury T, Fehring TK, Taunton M, Hanssen A, Azzam K, Parvizi J, et al. The fate of acute methicillinresistant Staphylococcus aureus periprosthetic knee infections treated by open debridement and retention of components. J Arthroplasty. 2009;24 (Suppl 6):101-4.

  7. Brandt CM, Sistrunk WW, Duffy MC, Hanssen AD, Steckelberg JM, Ilstrup DM, et al. Staphylococcus aureus prosthetic joint infection treated with debridement and prosthesis retention. Clin Infect Dis. 1997; 24(5):914-9.

  8. Hartman MB, Fehring TK, Jordan L, Norton HJ. Periprosthetic knee sepsis. The role of irrigation and debridement. Clin Orthop Relat Res. 1991;(273):113-8.

  9. Marculescu CE, Berbari EF, Hanssen AD, Steckelberg JM, Harmsen SW, Mandrekar JN, et al. Outcome of prosthetic joint infections treated with debridement and retention of components. Clin Infect Dis. 2006;42(4):471-8.

  10. Amato SM, Fazen CH, Henry TC, Mok WWK, Orman MA, Sandvik EL, et al. The role of metabolism in bacterial persistence. Front Microbiol. 2014;5:70.

  11. Aragón-Sánchez FJ, Cabrera-Galván JJ, Quintana- Marrero Y, Hernández-Herrero MJ, Lázaro-Martínez JL, García-Morales E, et al. Outcomes of surgical treatment of diabetic foot osteomyelitis: a series of 185 patients with histopathological confirmation of bone involvement. Diabetologia. 2008;51(11):1962-70.

  12. González-Cruz J, Kafatti R, López-Flores A. Frecuencia de infecciones nosocomiales en pacientes postoperados selectivos del servicio de ortopedia y traumatología del bloque medico quirúrgico (bmq) del hospital escuela durante el periodo de marzo 2000 a septiembre del año 2002. Rev Med Post UNAH. 2003;8(1):1-6.

  13. Jover-Sáenz A, Barcenilla-Gaite F, Torres-Puig Gros J, Mas-Atance J, Garrido-Calvo S, Porcel-Pérez JM. Infección de prótesis total de rodilla y cadera. Epidemiología descriptiva, terapéutica y evolución en un hospital de segundo nivel durante 10 años. An Med Interna. 2007;24(1):19-23.

  14. Padgett D, Luque MT, Rivera DM, Zepeda LM, Hernandez AL. Vigilancia de infecciones nosocomiales: Experiencia de un hospital de especialidades del Instituto Hondureño de Seguridad Social 2006-2012. Rev Medica Honduras. 2013;81(2):68-72.

  15. Kłuciński P, Ekiel A, Wilk I, Martirosian G. Re: Karamanis EM, Matthaiou DK, Moraitis LI, et al. Fluoroquinolones versus beta-lactam based regimens for the treatment of osteomyelitis: a meta-analysis of randomized controlled trials. Spine 2008;33:E297- E304. Spine. 2009;34(4):420-1.

  16. Lazzarini L, Lipsky BA, Mader JT. Antibiotic treatment of osteomyelitis: what have we learned from 30 years of clinical trials? Int J Infect Dis. 2005;9(3): 127-38.

  17. Chihara S, Segreti J. Osteomyelitis. Dis Mon. 2010; 56(1):5-31.

  18. Waldvogel FA, Medoff G, Schwartz MN. Osteomyelitis: a review of clinical features, therapeutic considerations and unusual aspects. 3. Osteomyelitis associated with vascular insufficiency. N Engl J Med. 1970;282(6):316-22.

  19. Pääkkönen M, Kallio MJ, Peltola H, Kallio PE. Antibiotic Treatment and Surgery for Acute Hematogenous Calcaneal Osteomyelitis of Childhood. J Foot Ankle Surg. 2015;54(5):840-3.

  20. Godley DR. Managing musculoskeletal infections in children in the era of increasing bacterial resistance. JAAPA. 2015;28(4):24-9.

  21. Waldvogel FA, Medoff G, Swartz MN. Osteomyelitis: a review of clinical features, therapeutic considerations and unusual aspects (second of three parts). N Engl J Med. 1970;282(5):260-6.

  22. Mader JT, Cantrell JS, Calhoun J. Oral ciprofloxacin compared with standard parenteral antibiotic therapy for chronic osteomyelitis in adults. J Bone Joint Surg Am. 1990;72(1):104-10.

  23. Gentry LO, Rodriguez GG. Oral ciprofloxacin compared with parenteral antibiotics in the treatment of osteomyelitis. Antimicrob Agents Chemother. 1990; 34(1):40-3.

  24. Farhad R, Roger PM, Albert C, Pélligri C, Touati C, Dellamonica P, et al. Six weeks antibiotic therapy for all bone infections: results of a cohort study. Eur J Clin Microbiol Infect Dis. 2010;29(2):217-22.

  25. Esposito S, Leone S, Bassetti M, Borrè S, Leoncini F, Meani E, et al. Italian guidelines for the diagnosis and infectious disease management of osteomyelitis and prosthetic joint infections in adults. Infection. 2009;37(6):478-96.

  26. Zimmerli W, Widmer AF, Blatter M, Frei R, Ochsner PE. Role of rifampin for treatment of orthopedic implant- related staphylococcal infections: a randomized controlled trial. Foreign-Body Infection (FBI) Study Group. JAMA. 1998;279(19):1537-41.

  27. Krenn V, Morawietz L, Kienapfel H, Ascherl R, Matziolis G, Hassenpflug J, et al. Revised consensus classification. Histopathological classification of diseases associated with joint endoprostheses. Z Rheumatol. 2013;72(4):383-92.






>Journals >Revista Médica del Instituto Mexicano del Seguro Social >Year 2016, Issue S3
 

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