León-Quintero LM, Sánchez DLE, Moreno AJA

Idioma: Español
Referencias bibliográficas: 33
Paginas: 113-123
Archivo PDF: 227.54 Kb.

RESUMEN

La alopecia androgenética y otros tipos de pérdida de cabello representan un problema altamente prevalente con importante impacto psicosocial, cuyo manejo se ve limitado por la eficacia parcial y los efectos adversos de terapias aprobadas como minoxidil o finasterida. Este trabajo ofrece una revisión narrativa de la evidencia preclínica y clínica de Serenoa repens (saw palmetto), para la pérdida de cabello. Se sintetizan datos que muestran efectos antiandrogénicos (inhibición de la 5α-reductasa, modulación de la señalización androgénica), así como acciones antioxidantes, antiinflamatorias y su influencia sobre los factores de crecimiento implicados en la biología del folículo piloso. Se revisan estudios intervencionales y observacionales que evalúan formulaciones orales y tópicas de Serenoa repens en alopecia androgenética y efluvio telógeno, los cuales sugieren estabilización de la enfermedad y mejoras en densidad, calidad y caída del cabello, con un perfil de seguridad generalmente favorable. No obstante, la heterogeneidad de las formulaciones, dosis y diseños de estudio limita la comparabilidad y la validez externa de los hallazgos. Se discuten las motivaciones de los pacientes hacia terapias “naturales”, las implicaciones regulatorias de su condición de suplemento y se identifican prioridades de investigación futura, incluyendo ensayos controlados y plataformas avanzadas de liberación tópica.

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